Gene
ccn1
- ID
- ZDB-GENE-040426-3
- Name
- cellular communication network factor 1
- Symbol
- ccn1 Nomenclature History
- Previous Names
-
- cyr61
- zCyr61-c23 (1)
- zgc:85866
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable heparin binding activity and integrin binding activity. Acts upstream of or within fin regeneration. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including brain; endocrine system; epidermis; hypochord; and neural plate. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human CCN1 (cellular communication network factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85866 (23 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| zju112Tg | Transgenic insertion | Unknown | Unknown | DNA |
1 - 1 of 1
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CCN, TSP1 domain | Cellular Communication Network Factor | Cystine knot, C-terminal | Glycoprotein hormone subunit beta | Growth factor receptor cysteine-rich domain superfamily | IGFBP-related, CNN | Insulin-like growth factor-binding protein, IGFBP | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily | VWFC domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QL10 | InterPro | 369 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | ZFOS-90C9 | ZFIN Curated Data | |
| Encodes | EST | fc86f04 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:85866 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001001826 (1) | 2542 nt | ||
| Genomic | GenBank:CU672235 (2) | 35262 nt | ||
| Polypeptide | UniProtKB:F1QL10 (1) | 369 aa |
- Camacho-Macorra, C., Tabanera, N., Sánchez-Bustamante, E., Bovolenta, P., Cardozo, M.J. (2024) Maternal vgll4a regulates zebrafish epiboly through Yap1 activity. Frontiers in cell and developmental biology. 12:13626951362695
- Chen, M., Liu, Y., Zuo, M., Guo, C., Du, Y., Xu, H., Liu, B., Li, M., Xiao, W., Yu, G. (2024) NEDD8 enhances Hippo signaling by mediating YAP1 neddylation. The Journal of biological chemistry. 300(8):107512
- El Maï, M., Bird, M., Allouche, A., Targen, S., Şerifoğlu, N., Lopes-Bastos, B., Guigonis, J.M., Kang, D., Pourcher, T., Yue, J.X., Ferreira, M.G. (2023) Gut-specific telomerase expression counteracts systemic aging in telomerase-deficient zebrafish. Nature aging. 3(5):567-584
- Toh, P.J.Y., Lai, J.K.H., Hermann, A., Destaing, O., Sheetz, M.P., Sudol, M., Saunders, T.E. (2022) Optogenetic control of YAP cellular localisation and function. EMBO reports. 23(9):e54401
- Camillo, C., Facchinello, N., Villari, G., Mana, G., Gioelli, N., Sandri, C., Astone, M., Tortarolo, D., Clapero, F., Gays, D., Oberkersch, R.E., Arese, M., Tamagnone, L., Valdembri, D., Santoro, M.M., Serini, G. (2021) LPHN2 inhibits vascular permeability by differential control of endothelial cell adhesion. The Journal of cell biology. 220(11):
- Flinn, M.A., Otten, C., Brandt, Z.J., Bostrom, J.R., Kenarsary, A., Wan, T.C., Auchampach, J.A., Abdelilah-Seyfried, S., O'Meara, C.C., Link, B.A. (2020) Llgl1 regulates zebrafish cardiac development by mediating Yap stability in cardiomyocytes. Development (Cambridge, England). 147(16):
- Liu, D.J., Zhang, F., Chen, Y., Jin, Y., Zhang, Y.L., Chen, S.B., Xie, Y.Y., Huang, Q.H., Zhao, W.L., Wang, L., Xu, P.F., Chen, Z., Chen, S.J., Li, B., Zhang, A., Sun, X.J. (2020) setd2 knockout zebrafish is viable and fertile: differential and developmental stress-related requirements for Setd2 and histone H3K36 trimethylation in different vertebrate animals. Cell discovery. 6:72
- Marques, F.G., Carvalho, L., Sousa, J.S., Rino, J., Diegues, I., Poli, E., Pina, F., Saúde, L., Constantino Rosa Santos, S. (2020) Low doses of ionizing radiation enhance angiogenesis and consequently accelerate post-embryonic development but not regeneration in zebrafish. Scientific Reports. 10:3137
- Sinnberg, T., Levesque, M.P., Krochmann, J., Cheng, P.F., Ikenberg, K., Meraz-Torres, F., Niessner, H., Garbe, C., Busch, C. (2018) Wnt-signaling enhances neural crest migration of melanoma cells and induces an invasive phenotype. Molecular Cancer. 17:59
- Xu, D., Lv, J., He, L., Fu, L., Hu, R., Cao, Y., Mei, C. (2018) Scribble influences cyst formation in autosomal-dominant polycystic kidney disease by regulating Hippo signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(8):4394-4407
1 - 10 of 24
Show