Gene

exo1

ID

ZDB-GENE-040426-2828

Name

exonuclease 1

Symbol

exo1 Nomenclature History

Previous Names

fc16e04 (1)
wu:fc16e04 (1)
zgc:55521 (1)

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable 5'-flap endonuclease activity and single-stranded DNA 5'-3' exodeoxyribonuclease activity. Predicted to be involved in DNA recombination and mismatch repair. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be active in nucleus. Is expressed in proliferative region. Orthologous to human EXO1 (exonuclease 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7149750 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With exo1 Human Ortholog

No data available

Associated With exo1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR008918	Helix-hairpin-helix motif, class 2
Conserved_site	IPR019974	XPG conserved site
Domain	IPR006085	XPG, N-terminal
Domain	IPR006086	XPG-I domain
Domain	IPR037315	Exonuclease-1, H3TH domain
Domain	IPR044752	Exonuclease 1-like, PIN-like domain
Family	IPR006084	XPG/Rad2 endonuclease
Homologous_superfamily	IPR029060	PIN-like domain superfamily
Homologous_superfamily	IPR036279	5'-3' exonuclease, C-terminal domain superfamily
Repeat	IPR019734	Tetratricopeptide repeat

Domain Details Per Protein

Protein	Length	5'-3' exonuclease, C-terminal domain superfamily	Exonuclease-1, H3TH domain	Exonuclease 1-like, PIN-like domain	Helix-hairpin-helix motif, class 2	PIN-like domain superfamily	Tetratricopeptide repeat	XPG conserved site	XPG-I domain	XPG, N-terminal	XPG/Rad2 endonuclease
UniProtKB:Q803U7 InterPro	806

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	exo1-201 (1) Ensembl	Ensembl	2,735 nt	Select Tool ZFIN BLAST
mRNA	exo1-202 (1) Ensembl	Ensembl	547 nt	Select Tool ZFIN BLAST
mRNA	exo1-203 (1) Ensembl	Ensembl	811 nt	Select Tool ZFIN BLAST
mRNA	exo1-205 (1) Ensembl	Ensembl	5,010 nt	Select Tool ZFIN BLAST
ncRNA	exo1-004 (1) Ensembl	Ensembl	608 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations