Gene

rffl

ID

ZDB-GENE-040426-2274

Name

ring finger and FYVE-like domain containing E3 ubiquitin protein ligase

Symbol

rffl Nomenclature History

Previous Names

zgc:77828

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of apoptotic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein K48-linked ubiquitination. Predicted to act upstream of or within apoptotic process. Predicted to be located in membrane. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human RFFL (ring finger and FYVE like domain containing E3 ubiquitin protein ligase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rffl Human Ortholog

No data available

Associated With rffl Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR049320	E3 ubiquitin-protein ligase CARP1/2, FYVE/PHD zinc finger
Domain	IPR049322	E3 ubiquitin-protein ligase CARP2, FYVE/PHD zinc finger
Family	IPR051728	RING-FYVE domain-containing E3 ubiquitin-protein ligase
Homologous_superfamily	IPR011011	Zinc finger, FYVE/PHD-type
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR036361	SAP domain superfamily