Gene

tead1a

ID

ZDB-GENE-040426-2101

Name

TEA domain family member 1a

Symbol

tead1a Nomenclature History

Previous Names

tead1
zgc:63696

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within Kupffer's vesicle development; cilium assembly; and determination of heart left/right asymmetry. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Is expressed in nervous system; neural plate; and somite. Human ortholog(s) of this gene implicated in Sveinsson chorioretinal atrophy. Orthologous to human TEAD1 (TEA domain transcription factor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:63696 (23 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Fillatre et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tead1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Sveinsson chorioretinal atrophy	Alliance	Sveinsson chorioretinal atrophy	108985

Associated With tead1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000818	TEA/ATTS domain
Domain	IPR041086	YAP binding domain
Family	IPR016361	Transcriptional enhancer factor, metazoa
Family	IPR050937	TEC1/TEAD Transcription Factor
Homologous_superfamily	IPR038096	TEA/ATTS domain superfamily

Domain Details Per Protein

Protein	Length	TEA/ATTS domain	TEA/ATTS domain superfamily	TEC1/TEAD Transcription Factor	Transcriptional enhancer factor, metazoa	YAP binding domain
UniProtKB:A0A8M3B730 InterPro	422
UniProtKB:Q7SXX3 InterPro	393

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tead1a-201 (1) Ensembl	Ensembl	748 nt	Select Tool ZFIN BLAST
mRNA	tead1a-202 (1) Ensembl	Ensembl	1,744 nt	Select Tool ZFIN BLAST
ncRNA	tead1a-003 (1) Ensembl	Ensembl	817 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations