ZFIN is now using GRCz12tu for Genomic Data

Gene

asah1b

ID

ZDB-GENE-040426-1512

Name

N-acylsphingosine amidohydrolase (acid ceramidase) 1b

Symbol

asah1b Nomenclature History

Previous Names

zgc:66026

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Enables N-acylsphingosine amidohydrolase activity. Acts upstream of or within several processes, including collateral sprouting; glucosylceramide catabolic process; and swimming behavior. Predicted to be located in extracellular region and lysosome. Is expressed in bone tissue; brain; gill; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Farber lipogranulomatosis; sphingolipidosis; and spinal muscular atrophy with progressive myoclonic epilepsy. Orthologous to human ASAH1 (N-acylsphingosine amidohydrolase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu946 (1 image)
IMAGE:7165391 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With asah1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Farber lipogranulomatosis	Alliance	Farber lipogranulomatosis	228000
spinal muscular atrophy with progressive myoclonic epilepsy	Alliance	Spinal muscular atrophy with progressive myoclonic epilepsy	159950

Associated With asah1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR029130	Acid ceramidase, N-terminal
Domain	IPR029132	Choloylglycine hydrolase/NAAA C-terminal
Family	IPR016699	Acid ceramidase-like

Domain Details Per Protein

Protein	Additional Resources	Length	Acid ceramidase-like	Acid ceramidase, N-terminal	Choloylglycine hydrolase/NAAA C-terminal
UniProtKB:Q6PH71	InterPro	395

Transcripts

Genome Browsers

NCBI Map Viewer

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	asah1b-201 (1) Ensembl	Ensembl		1,726 nt	Select Tool ZFIN BLAST
ncRNA	asah1b-002 (1) Ensembl	Ensembl		538 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations