Gene

cisd2

ID

ZDB-GENE-040426-1381

Name

CDGSH iron sulfur domain 2

Symbol

cisd2 Nomenclature History

Previous Names

zgc:64148

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have 2 iron, 2 sulfur cluster binding activity and protein homodimerization activity. Predicted to be involved in autophagy of mitochondrion; multicellular organism aging; and regulation of autophagy. Predicted to localize to endoplasmic reticulum membrane and mitochondrial outer membrane. Human ortholog(s) of this gene implicated in Wolfram syndrome 2. Orthologous to human CISD2 (CDGSH iron sulfur domain 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:64148 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cisd2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Wolfram syndrome 2	Alliance	Wolfram syndrome 2	604928

Associated With cisd2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR018967	Iron-binding zinc finger, CDGSH type
Domain	IPR019610	Iron sulphur domain-containing, mitoNEET, N-terminal
Family	IPR045131	CDGSH iron-sulfur domain-containing protein 1/2
Homologous_superfamily	IPR042216	MitoNEET, CDGSH iron-sulfur domain