Gene
cdc73
- ID
- ZDB-GENE-040426-1309
- Name
- cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
- Symbol
- cdc73 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have RNA polymerase II complex binding activity. Involved in erythrocyte differentiation; regulation of transcription elongation from RNA polymerase II promoter; and spinal cord oligodendrocyte cell differentiation. Localizes to Cdc73/Paf1 complex. Human ortholog(s) of this gene implicated in hyperparathyroidism and parathyroid carcinoma. Orthologous to human CDC73 (cell division cycle 73).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63956 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hyperparathyroidism | Alliance | Hyperparathyroidism, familial primary | 145000 |
| hyperparathyroidism | Alliance | Hyperparathyroidism-jaw tumor syndrome | 145001 |
| hyperparathyroidism | Alliance | Parathyroid adenoma with cystic changes | 145001 |
| parathyroid carcinoma | Alliance | Parathyroid carcinoma | 608266 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cdc73/Parafibromin | Cell division control protein 73, C-terminal | Cell division control protein 73, C-terminal domain superfamily | Paf1 complex subunit Cdc73, N-terminal domain |
|---|---|---|---|---|---|
|
UniProtKB:Q7T3D4
|
521 | ||||
|
UniProtKB:X1WHN7
|
530 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-cdc73 | polyclonal | IgG | Rabbit |
|
Sigma-Aldrich
|
2 |
Plasmids
No data available