Gene
nt5e
- ID
- ZDB-GENE-040426-1261
- Name
- 5'-nucleotidase, ecto (CD73)
- Symbol
- nt5e Nomenclature History
- Previous Names
-
- zgc:63784
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have 5'-nucleotidase activity. Involved in response to copper ion. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in hereditary arterial and articular multiple calcification syndrome. Is expressed in brain and intestinal bulb. Orthologous to human NT5E (5'-nucleotidase ecto).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63784 (3 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary arterial and articular multiple calcification syndrome | Alliance | Calcification of joints and arteries | 211800 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR006146 | 5'-Nucleotidase, conserved site |
| Domain | IPR004843 | Calcineurin-like phosphoesterase domain, ApaH type |
| Domain | IPR008334 | 5'-Nucleotidase, C-terminal |
| Family | IPR006179 | 5'-Nucleotidase/apyrase |
| Homologous_superfamily | IPR029052 | Metallo-dependent phosphatase-like |
| Homologous_superfamily | IPR036907 | 5'-Nucleotidase, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | 5'-Nucleotidase/apyrase | 5'-Nucleotidase, conserved site | 5'-Nucleotidase, C-terminal | 5'-Nucleotidase, C-terminal domain superfamily | Calcineurin-like phosphoesterase domain, ApaH type | Metallo-dependent phosphatase-like |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7SXU4
|
571 |
Interactions and Pathways
No data available
Plasmids
No data available