Gene
foxl1
- ID
- ZDB-GENE-040426-1181
- Name
- forkhead box L1
- Symbol
- foxl1 Nomenclature History
- Previous Names
-
- zgc:63595
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity. Acts upstream of or within several processes, including cartilage morphogenesis; pectoral fin morphogenesis; and regulation of bone mineralization. Predicted to be located in nucleus. Is expressed in several structures, including brain; digestive system; head; pleuroperitoneal region; and presumptive neural retina. Used to study osteoporosis and otosclerosis. Human ortholog(s) of this gene implicated in otosclerosis 11. Orthologous to human FOXL1 (forkhead box L1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-foxl1 | Hawkey-Noble et al., 2022 | |
| MO1-foxl1 | N/A | Nakada et al., 2006 |
| MO2-foxl1 | N/A | Nakada et al., 2006 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| otosclerosis 11 | Alliance | Otosclerosis 11 | 620576 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| otosclerosis | foxl1nfl1/nfl1 (AB) | standard conditions | Hawkey-Noble et al., 2022 |
| osteoporosis | foxl1nfl1/nfl1 (AB) | standard conditions | Hawkey-Noble et al., 2022 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018122 | Fork head domain conserved site1 |
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR001766 | Fork head domain |
| Domain | IPR047514 | Forkhead box protein L1, forkhead domain |
| Family | IPR050211 | Forkhead box domain-containing protein |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Forkhead box domain-containing protein | Forkhead box protein L1, forkhead domain | Fork head domain | Fork head domain conserved site1 | Fork head domain conserved site 2 | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7SY22 | InterPro | 363 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-102F14 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:63595 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200984 (1) | 1889 nt | ||
| Genomic | GenBank:BX908765 (1) | 155120 nt | ||
| Polypeptide | UniProtKB:Q7SY22 (1) | 363 aa |
- Hawkey-Noble, A., Pater, J.A., Kollipara, R., Fitzgerald, M., Maekawa, A.S., Kovacs, C.S., Young, T.L., French, C.R. (2022) Mutation of foxl1 Results in Reduced Cartilage Markers in a Zebrafish Model of Otosclerosis. Genes. 13(7):
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Tarashansky, A.J., Musser, J.M., Khariton, M., Li, P., Arendt, D., Quake, S.R., Wang, B. (2021) Mapping single-cell atlases throughout Metazoa unravels cell type evolution. eLIFE. 10:
- Huang, W., Ai, W., Lin, W., Fang, F., Wang, X., Huang, H., Dahlgren, R.A., Wang, H. (2020) Identification of receptors for eight endocrine disrupting chemicals and their underlying mechanisms using zebrafish as a model organism. Ecotoxicology and environmental safety. 204:111068
- Zeng, C.W., Sheu, J.C., Tsai, H.J. (2020) A new member of the forkhead box protein family in zebrafish: Domain composition, phylogenetic implication and embryonic expression pattern. Gene expression patterns : GEP. 35:119093
- Xu, P., Balczerski, B., Ciozda, A., Louie, K., Oralova, V., Huysseune, A., Crump, J.G. (2018) Fox proteins are modular competency factors for facial cartilage and tooth specification. Development (Cambridge, England). 145(12)
- Yang, Y.J., Wang, Y., Li, Z., Zhou, L., Gui, J.F. (2017) Sequential, Divergent, and Cooperative Requirements of Foxl2a and Foxl2b in Ovary Development and Maintenance of Zebrafish.. Genetics. 205(4):1551-1572
- Tang, V., Cofer, Z.C., Cui, S., Sapp, V., Loomes, K.M., Matthews, R.P. (2016) Loss of a Candidate Biliary Atresia Susceptibility Gene, add3a, Causes Biliary Developmental Defects in Zebrafish. Journal of pediatric gastroenterology and nutrition. 63(5):524-530
- Cui, S., Leyva-Vega, M., Tsai, E.A., Eauclaire, S.F., Glessner, J.T., Hakonarson, H., Devoto, M., Haber, B.A., Spinner, N.B., and Matthews, R.P. (2013) Evidence from Human and Zebrafish that GPC1 is a Biliary Atresia Susceptibility Gene. Gastroenterology. 144(5):1107-1115
- Zheng, W., Wang, Z., Collins, J.E., Andrews, R.M., Stemple, D., and Gong, Z. (2011) Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and Mammalian lung. PLoS One. 6(8):e24019
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