Gene

rapgef1b

ID

ZDB-GENE-040426-1001

Name

Rap guanine nucleotide exchange factor (GEF) 1b

Symbol

rapgef1b Nomenclature History

Previous Names

rapgef1
zgc:56372 (1)

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have guanyl-nucleotide exchange factor activity. Predicted to be involved in small GTPase mediated signal transduction. Orthologous to human RAPGEF1 (Rap guanine nucleotide exchange factor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56372 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rapgef1b Human Ortholog

No data available

Associated With rapgef1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019804	Ras guanine-nucleotide exchange factor, conserved site
Domain	IPR000651	Ras-like guanine nucleotide exchange factor, N-terminal
Domain	IPR001895	Ras guanine-nucleotide exchange factors catalytic domain
Family	IPR008937	Ras-like guanine nucleotide exchange factor
Homologous_superfamily	IPR023578	Ras guanine nucleotide exchange factor domain superfamily
Homologous_superfamily	IPR036964	Ras guanine-nucleotide exchange factor, catalytic domain superfamily

Domain Details Per Protein

Protein	Length	Ras guanine-nucleotide exchange factor, catalytic domain superfamily	Ras guanine-nucleotide exchange factor, conserved site	Ras guanine nucleotide exchange factor domain superfamily	Ras guanine-nucleotide exchange factors catalytic domain	Ras-like guanine nucleotide exchange factor	Ras-like guanine nucleotide exchange factor, N-terminal
UniProtKB:E7F4B2 InterPro	1188
UniProtKB:A0A8M9PQB1 InterPro	1203
UniProtKB:A0A8M9PI61 InterPro	1101
UniProtKB:A0A8M9P382 InterPro	1183
UniProtKB:A0A8M9PTQ9 InterPro	1204
UniProtKB:A0A8M9PCJ2 InterPro	1155

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rapgef1b-201 (1) Ensembl	Ensembl	4,332 nt	Select Tool ZFIN BLAST
mRNA	rapgef1b-203 (1) Ensembl	Ensembl	1,710 nt	Select Tool
mRNA	rapgef1b-204 (1) Ensembl	Ensembl	2,119 nt	Select Tool
ncRNA	rapgef1b-003 (1) Ensembl	Ensembl	944 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations