Gene
alpl
- ID
- ZDB-GENE-040420-1
- Name
- alkaline phosphatase, biomineralization associated
- Symbol
- alpl Nomenclature History
- Previous Names
-
- alp (1)
- zgc:56672
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable alkaline phosphatase activity. Acts upstream of or within bone mineralization and response to mechanical stimulus. Predicted to be located in side of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including anterior neural keel; brain; cardiovascular system; eye; and opercular flap. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; and infantile hypophosphatasia. Orthologous to human ALPL (alkaline phosphatase, biomineralization associated).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 41 figures from 30 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56672 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la011993Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa41854 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-alpl | N/A | Ohlebusch et al., 2020 |
| MO2-alpl | N/A | Ohlebusch et al., 2020 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| adult hypophosphatasia | Alliance | Hypophosphatasia, adult | 146300 |
| adult hypophosphatasia | Alliance | Odontohypophosphatasia | 146300 |
| childhood hypophosphatasia | Alliance | Hypophosphatasia, childhood | 241510 |
| infantile hypophosphatasia | Alliance | Hypophosphatasia, infantile | 241500 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Alkaline phosphatase | Alkaline phosphatase, active site | Alkaline-phosphatase-like, core domain superfamily |
|---|---|---|---|---|
|
UniProtKB:F1Q5B5
|
561 | |||
|
UniProtKB:A0A8M9PUR2
|
554 | |||
|
UniProtKB:A0A8M2BGI2
|
527 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(alpl:mCherry) |
|
| 1 | (6) | |
| Tg(alpl:NLS-EGFP) |
|
| 1 | Kozak et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-220M17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56672 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201007 (1) | 3712 nt | ||
| Genomic | GenBank:BX248318 (1) | 194209 nt | ||
| Polypeptide | UniProtKB:F1Q5B5 (1) | 561 aa |
- Cotti, S., Di Biagio, C., Huysseune, A., Koppe, W., Forlino, A., Witten, P.E. (2024) Matrix first, minerals later: fine-tuned dietary phosphate increases bone formation in zebrafish. JBMR plus. 8:ziae081ziae081
- Jiang, R.X., Hu, N., Deng, Y.W., Hu, L.W., Gu, H., Luo, N., Wen, J., Jiang, X.Q. (2024) Potential therapeutic role of spermine via Rac1 in osteoporosis: Insights from zebrafish and mice. Zoological research. 45:367380367-380
- Niu, M., Whang, H., Wu, Z., ShouwenJiang, ., Chen, L. (2024) The deletion of Asb15b gene can lead to a significant decrease in zebrafish intermuscular bone. Gene. 923:148561
- Arachchilage Hasitha Maduranga Karunarathne, W., Hyun Choi, Y., Lee, M.H., Kang, C.H., Kim, G.Y. (2023) Gamma-aminobutyric acid (GABA)-mediated bone formation and its implications for anti-osteoporosis strategies: Exploring the relation between GABA and GABA receptors. Biochemical pharmacology. 218:115888115888
- Carletti, A., Rosa, J.T., Pes, K., Borges, I., Santos, T., Barreira, L., Varela, J., Pereira, H., Cancela, M.L., Gavaia, P.J., Laizé, V. (2023) The osteogenic and mineralogenic potential of the microalgae Skeletonema costatum and Tetraselmis striata CTP4 in fish models. Cellular and molecular life sciences : CMLS. 80:310310
- Zhong, Y.T., Liao, H.B., Ye, Z.Q., Jiang, H.S., Li, J.X., Ke, L.M., Hua, J.Y., Wei, B., Wu, X., Cui, L. (2023) Eurycomanone stimulates bone mineralization in zebrafish larvae and promotes osteogenic differentiation of mesenchymal stem cells by upregulating AKT/GSK-3β/β-catenin signaling. Journal of orthopaedic translation. 40:132146132-146
- Dalle Carbonare, L., Bertacco, J., Gaglio, S.C., Minoia, A., Cominacini, M., Cheri, S., Deiana, M., Marchetto, G., Bisognin, A., Gandini, A., Antoniazzi, F., Perduca, M., Mottes, M., Valenti, M.T. (2022) Fisetin: An Integrated Approach to Identify a Strategy Promoting Osteogenesis. Frontiers in pharmacology. 13:890693
- Maduranga Karunarathne, W.A.H., Choi, Y.H., Park, S.R., Lee, C.M., Kim, G.Y. (2022) Bisphenol A inhibits osteogenic activity and causes bone resorption via the activation of retinoic acid-related orphan receptor α. Journal of hazardous materials. 438:129458
- Nie, C.H., Wan, S.M., Chen, Y.L., Huysseune, A., Wu, Y.M., Zhou, J.J., Hilsdorf, A.W.S., Wang, W.M., Witten, P.E., Lin, Q., Gao, Z.X. (2022) Single-cell transcriptomes and runx2b-/- mutants reveal the genetic signatures of intermuscular bone formation in zebrafish. National science review. 9:nwac152nwac152
- Peng, C.H., Lin, W.Y., Li, C.Y., Dharini, K.K., Chang, C.Y., Hong, J.T., Lin, M.D. (2022) Gu Sui Bu (Drynaria fortunei J. Sm.) antagonizes glucocorticoid-induced mineralization reduction in zebrafish larvae by modulating the activity of osteoblasts and osteoclasts. Journal of ethnopharmacology. 297:115565
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