ZFIN is now using GRCz12tu for Genomic Data
Gene
alpl
- ID
- ZDB-GENE-040420-1
- Name
- alkaline phosphatase, biomineralization associated
- Symbol
- alpl Nomenclature History
- Previous Names
-
- alp (1)
- zgc:56672
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables alkaline phosphatase activity. Acts upstream of or within bone mineralization; response to mechanical stimulus; and vitamin B6 metabolic process. Predicted to be active in plasma membrane. Is expressed in several structures, including anterior neural keel; brain; cardiovascular system; eye; and opercular flap. Used to study hypophosphatasia. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; and infantile hypophosphatasia. Orthologous to human ALPL (alkaline phosphatase, biomineralization associated).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 47 figures from 35 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56672 (10 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| adult hypophosphatasia | Alliance | Hypophosphatasia, adult | 146300 |
| adult hypophosphatasia | Alliance | Odontohypophosphatasia | 146300 |
| childhood hypophosphatasia | Alliance | Hypophosphatasia, childhood | 241510 |
| infantile hypophosphatasia | Alliance | Hypophosphatasia, infantile | 241500 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| hypophosphatasia | alplzf4270/zf4270 (TL) | standard conditions | Ciapaite et al., 2025 |
| hypophosphatasia | alplwue7/wue7 (AB) | standard conditions | Hark et al., 2025 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Alkaline phosphatase | Alkaline phosphatase, active site | Alkaline-phosphatase-like, core domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:F1Q5B5 | InterPro | 561 | |||
| UniProtKB:A0A8M9PUR2 | InterPro | 554 | |||
| UniProtKB:A0A8M2BGI2 | InterPro | 527 | |||
| UniProtKB:A0AB32TZ69 | InterPro | 463 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-alpl | polyclonal | Rabbit |
|
Sigma-Aldrich
|
2 |
Plasmids
No data available
- Genome Browsers