ZFIN is now using GRCz12tu for Genomic Data
Gene
gjb8
- ID
- ZDB-GENE-040406-1
- Name
- gap junction protein beta 8
- Symbol
- gjb8 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables gap junction channel activity. Acts upstream of or within auditory behavior; neuromast development; and otic vesicle development. Predicted to be located in gap junction and plasma membrane. Predicted to be part of connexin complex. Is expressed in several structures, including cardiovascular system; fin; integument; pleuroperitoneal region; and sensory system. Used to study nonsyndromic deafness. Human ortholog(s) of this gene implicated in several diseases, including Bart-Pumphrey syndrome; Vohwinkel syndrome; auditory system disease (multiple); autosomal dominant keratitis-ichthyosis-deafness syndrome; and ectodermal dysplasia (multiple). Orthologous to several human genes including GJB2 (gap junction protein beta 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant keratitis-ichthyosis-deafness syndrome | Alliance | Keratitis-ichthyosis-deafness syndrome | 148210 |
| autosomal dominant nonsyndromic deafness 3A | Alliance | Deafness, autosomal dominant 3A | 601544 |
| autosomal dominant nonsyndromic deafness 3B | Alliance | Deafness, autosomal dominant 3B | 612643 |
| autosomal recessive nonsyndromic deafness 1A | Alliance | Deafness, autosomal recessive 1A | 220290 |
| autosomal recessive nonsyndromic deafness 1A | Alliance | Deafness, digenic GJB2/GJB6 | 220290 |
| autosomal recessive nonsyndromic deafness 1B | Alliance | Deafness, autosomal recessive 1B | 612645 |
| Bart-Pumphrey syndrome | Alliance | Bart-Pumphrey syndrome | 149200 |
| Clouston syndrome | Alliance | Ectodermal dysplasia 2, Clouston type | 129500 |
| palmoplantar keratoderma-deafness syndrome | Alliance | Keratoderma, palmoplantar, with deafness | 148350 |
| Vohwinkel syndrome | Alliance | Vohwinkel syndrome | 124500 |
| Hystrix-like ichthyosis with deafness | 602540 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| nonsyndromic deafness | AB + MO3-gjb8 | control | Chen et al., 2026 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Connexin | Connexin, conserved site | Connexin, cysteine-rich domain | Connexin, N-terminal | Connexin, N-terminal domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q503F4 | InterPro | 267 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cx30.3-201
(1)
|
Ensembl | 2,252 nt | ||
| mRNA |
cx30.3-202
(1)
|
Ensembl | 894 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers