Gene
cbx4
- ID
- ZDB-GENE-040329-2
- Name
- chromobox homolog 4 (Pc class homolog, Drosophila)
- Symbol
- cbx4 Nomenclature History
- Previous Names
-
- im:6911625
- zgc:158588
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable SUMO binding activity and SUMO ligase activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and protein sumoylation. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be part of PRC1 complex. Is expressed in several structures, including digestive system; eye; heart; pectoral fin bud; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human CBX4 (chromobox 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6911625 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa19977 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-cbx4 | N/A | Huang et al., 2013 |
| MO2-cbx4 | N/A | Huang et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CBX family C-terminal motif | Chromo/chromo shadow domain | Chromo domain | Chromo domain, conserved site | Chromo domain subgroup | Chromo-like domain superfamily | E3 SUMO-protein ligase CBX4 |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q804D1 | InterPro | 477 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-161I8 | ZFIN Curated Data | |
| Contained in | BAC | CH211-246E12 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6911625 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:158588 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198077 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198079 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205749 (1) | 1942 nt | ||
| Genomic | GenBank:CT573440 (1) | 159035 nt | ||
| Polypeptide | UniProtKB:Q804D1 (1) | 477 aa |
- Fang, X., Xu, S., Zhang, Y., Xu, J., Huang, Z., Liu, W., Wang, S., Yen, K., Zhang, W. (2021) Asxl1 C-terminal mutation perturbs neutrophil differentiation in zebrafish. Leukemia. 35(8):2299-2310
- Raby, L., Völkel, P., Le Bourhis, X., Angrand, P.O. (2020) The Polycomb Orthologues in Teleost Fishes and Their Expression in the Zebrafish Model. Genes. 11(4):
- Liu, J., Merkle, F.T., Gandhi, A.V., Gagnon, J.A., Woods, I.G., Chiu, C.N., Shimogori, T., Schier, A.F., Prober, D.A. (2015) Evolutionarily conserved regulation of hypocretin neuron specification by Lhx9. Development (Cambridge, England). 142(6):1113-24
- Sheng, Y., Zhao, W., Song, Y., Li, Z., Luo, M., Lei, Q., Cheng, H., Zhou, R. (2015) Proteomic analysis of three gonad types of swamp eel reveals genes differentially expressed during sex reversal.. Scientific Reports. 5:10176
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Le Faou, P., Völkel, P., and Angrand, P.O. (2011) The zebrafish genes encoding the Polycomb Repressive Complex (PRC) 1. Gene. 475(1):10-21
- Stewart, S., Tsun, Z.Y., and Izpisúa Belmonte, J.C. (2009) A histone demethylase is necessary for regeneration in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 106(47):19889-19894
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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