Gene
atp2b1a
- ID
- ZDB-GENE-030925-29
- Name
- ATPase plasma membrane Ca2+ transporting 1a
- Symbol
- atp2b1a Nomenclature History
- Previous Names
-
- pmca1a (1)
- sb:cb801
- si:dkey-18o7.1
- wu:fe47b06
- wu:fi41d01
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable P-type calcium transporter activity. Acts upstream of or within several processes, including bone mineralization; inner ear development; and sensory perception of sound. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle and plasma membrane. Is expressed in several structures, including digestive system; hematopoietic system; midbrain neural tube; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 66. Orthologous to human ATP2B1 (ATPase plasma membrane Ca2+ transporting 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb801 (12 images)
- IMAGE:7139107 (10 images)
- IMAGE:7165930 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-atp2b1a | N/A | Cruz et al., 2009 |
| MO2-atp2b1a | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 66 | Alliance | Intellectual developmental disorder, autosomal dominant 66 | 619910 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004014 | Cation-transporting P-type ATPase, N-terminal |
| Domain | IPR006068 | Cation-transporting P-type ATPase, C-terminal |
| Domain | IPR022141 | Plasma membrane calcium transporting P-type ATPase, C-terminal |
| Domain | IPR044492 | P-type ATPase, haloacid dehalogenase domain |
| Family | IPR001757 | P-type ATPase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cation-transporting P-type ATPase, C-terminal | Cation-transporting P-type ATPase, N-terminal | HAD-like superfamily | HAD superfamily | Plasma membrane calcium transporting P-type ATPase, C-terminal | P-type ATPase | P-type ATPase, A domain superfamily | P-type ATPase, cytoplasmic domain N | P-type ATPase, haloacid dehalogenase domain | P-type ATPase, phosphorylation site | P-type ATPase, subfamily IIB | P-type ATPase, transmembrane domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q0B2 | InterPro | 1257 | ||||||||||||
| UniProtKB:F6PDY7 | InterPro | 1228 | ||||||||||||
| UniProtKB:A0A8M9Q5T9 | InterPro | 1266 | ||||||||||||
| UniProtKB:A0A8M9QB28 | InterPro | 1188 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
atp2b1a-201
(1)
|
Ensembl | 5,951 nt | ||
| mRNA |
atp2b1a-202
(1)
|
Ensembl | 4,082 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-18O7 | ZFIN Curated Data | |
| Encodes | EST | cb801 | Thisse et al., 2001 | |
| Encodes | EST | fe47b06 | ZFIN Curated Data | |
| Encodes | EST | fi41d01 | ZFIN Curated Data | |
| Encodes | EST | fq35e10 | Rauch et al., 2003 | |
| Encodes | EST | IMAGE:7139107 | Thisse et al., 2004 | |
| Encodes | EST | IMAGE:7165930 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:198349 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044757 (1) | 5951 nt | ||
| Genomic | GenBank:BX649423 (2) | 182374 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q5T9 (1) | 1266 aa |
- Jędrychowska, J., Vardanyan, V., Wieczor, M., Marciniak, A., Czub, J., Amini, R., Jain, R., Shen, H., Choi, H., Kuznicki, J., Korzh, V. (2024) Mutant analysis of Kcng4b reveals how the different functional states of the voltage-gated potassium channel regulate ear development. Developmental Biology. 513:50-62
- Faria, M., Prats, E., Rosas Ramírez, J.R., Bellot, M., Bedrossiantz, J., Pagano, M., Valls, A., Gomez-Canela, C., Porta, J.M., Mestres, J., Garcia-Reyero, N., Faggio, C., Gómez Oliván, L.M., Raldua, D. (2021) Androgenic activation, impairment of the monoaminergic system and altered behavior in zebrafish larvae exposed to environmental concentrations of fenitrothion. The Science of the total environment. 775:145671
- Jedrychowska, J., Gasanov, E.V., Korzh, V. (2020) Kcnb1 plays a role in development of the inner ear. Developmental Biology. 471:65-75
- Langenbacher, A.D., Shimizu, H., Hsu, W., Zhao, Y., Borges, A., Koehler, C., Chen, J.N. (2020) Mitochondrial Calcium Uniporter Deficiency in Zebrafish Causes Cardiomyopathy With Arrhythmia. Frontiers in Physiology. 11:617492
- Tao, Y., Yang, Y., Jiao, Y., Wu, S., Zhu, G., Akindolie, M.S., Zhu, T., Qu, J., Wang, L., Zhang, Y. (2020) Monobutyl phthalate (MBP) induces energy metabolism disturbances in the gills of adult zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 266:115288
- Han, J., Liu, K., Wang, R., Zhang, Y., Zhou, B. (2019) Exposure to cadmium causes inhibition of otolith development and behavioral impairment in zebrafish larvae. Aquatic toxicology (Amsterdam, Netherlands). 214:105236
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Sonnack, L., Klawonn, T., Kriehuber, R., Hollert, H., Schäfers, C., Fenske, M. (2017) Comparative analysis of the transcriptome responses of zebrafish embryos after exposure to low concentrations of cadmium, cobalt and copper. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 25:99-108
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Hulsey, C.D., Fraser, G.J., Meyer, A. (2016) Biting into the Genome to Phenome Map: Developmental Genetic Modularity of Cichlid Fish Dentitions. Integrative and Comparative Biology. 56(3):373-88
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