ZFIN is now using GRCz12tu for Genomic Data
Gene
thoc1
- ID
- ZDB-GENE-030826-9
- Name
- THO complex 1
- Symbol
- thoc1 Nomenclature History
- Previous Names
-
- p84 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Acts upstream of or within regulation of apoptotic process. Predicted to be located in nuclear matrix. Predicted to be part of THO complex part of transcription export complex. Is expressed in nervous system; otic vesicle; pectoral fin; and post-vent region. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 86. Orthologous to human THOC1 (THO complex subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63738 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 8 figures from Zhang et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 86 | Alliance | ?Deafness, autosomal dominant 86 | 620280 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Death domain | Death-like domain superfamily | THO complex, subunit THOC1 |
|---|---|---|---|---|---|
| UniProtKB:Q7SYB2 | InterPro | 655 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers