Gene
slit1b
- ID
- ZDB-GENE-030722-4
- Name
- slit homolog 1b (Drosophila)
- Symbol
- slit1b Nomenclature History
- Previous Names
-
- chunp9742
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Acts upstream of or within cranial nerve morphogenesis. Predicted to be active in plasma membrane. Is expressed in central nervous system; forebrain; hindbrain; hindbrain nucleus; and retinal inner nuclear layer. Orthologous to human SLIT1 (slit guidance ligand 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Zecca et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6715 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa24209 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa37562 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa37563 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa43879 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43880 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa45778 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR013032 | EGF-like, conserved site |
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000372 | Leucine-rich repeat N-terminal domain |
| Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
| Domain | IPR000742 | EGF-like domain |
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Domain Details Per Protein
| Protein | Length | Concanavalin A-like lectin/glucanase domain superfamily | Cysteine-rich flanking region, C-terminal | Cystine knot, C-terminal | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | Laminin G domain | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat N-terminal domain | Leucine-rich repeat, typical subtype | Notch and Slit guidance protein |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q3Y6S4
|
1532 | |||||||||||||||
|
UniProtKB:A0A0R4IU60
|
1531 | |||||||||||||||
|
UniProtKB:A0A8M9PRT4
|
1241 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slit1b-201
(1)
|
Ensembl | 2,468 nt | ||
| mRNA |
slit1b-202
(1)
|
Ensembl | 1,919 nt | ||
| mRNA |
slit1b-203
(1)
|
Ensembl | 4,839 nt | ||
| mRNA |
slit1b-204
(1)
|
Ensembl | 5,117 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-389O21 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-208I21 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-347B23 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195126 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001034975 (1) | 5143 nt | ||
| Genomic | GenBank:CU855898 (2) | 85809 nt | ||
| Polypeptide | UniProtKB:Q3Y6S4 (1) | 1532 aa |
- Takeuchi, M., Yamaguchi, S., Yonemura, S., Kakiguchi, K., Sato, Y., Higashiyama, T., Shimizu, T., Hibi, M. (2015) Type IV Collagen Controls the Axogenesis of Cerebellar Granule Cells by Regulating Basement Membrane Integrity in Zebrafish. PLoS Genetics. 11:e1005587
- Zecca, A., Dyballa, S., Voltes, A., Bradley, R., Pujades, C. (2015) The Order and Place of Neuronal Differentiation Establish the Topography of Sensory Projections and the Entry Points within the Hindbrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:7475-86
- Schweitzer, J., Löhr, H., Bonkowsky, J.L., Hübscher, K., and Driever, W. (2013) Sim1a and Arnt2 contribute to hypothalamo-spinal axon guidance by regulating Robo2 activity via a Robo3-dependent mechanism. Development (Cambridge, England). 140(1):93-106
- Pan, Y.A., Choy, M., Prober, D.A., and Schier, A.F. (2012) Robo2 determines subtype-specific axonal projections of trigeminal sensory neurons. Development (Cambridge, England). 139(3):591-600
- Wong, G.K., Baudet, M.L., Norden, C., Leung, L., and Harris, W.A. (2012) Slit1b-robo3 signaling and N-cadherin regulate apical process retraction in developing retinal ganglion cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(1):223-2238
- Zhang, C., Gao, J., Zhang, H., Sun, L., and Peng, G. (2012) Robo2-Slit and Dcc-Netrin1 Coordinate Neuron Axonal Pathfinding within the Embryonic Axon Tracts. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(36):12589-12602
- Charoensawan, V., Adryan, B., Martin, S., Söllner, C., Thisse, B., Thisse, C., Wright, G.J., and Teichmann, S.A. (2010) The Impact of Gene Expression Regulation on Evolution of Extracellular Signaling Pathways. Molecular & cellular proteomics : MCP. 9(12):2666-2677
- Martin, S., Söllner, C., Charoensawan, V., Adryan, B., Thisse, B., Thisse, C., Teichmann, S.A., and Wright, G.J. (2010) Construction of a large extracellular protein interaction network and its resolution by spatiotemporal expression profiling. Molecular & cellular proteomics : MCP. 9(12):2654-2665
- Wyatt, C., Ebert, A., Reimer, M.M., Rasband, K., Hardy, M., Chien, C.B., Becker, T., and Becker, C.G. (2010) Analysis of the astray/robo2 Zebrafish Mutant Reveals that Degenerating Tracts Do Not Provide Strong Guidance Cues for Regenerating Optic Axons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(41):13838-13849
- Kastenhuber, E., Kern U., Bonkowsky, J.L., Chien, C.B., Driever, W., and Schweitzer, J. (2009) Netrin-DCC, Robo-Slit, and heparan sulfate proteoglycans coordinate lateral positioning of longitudinal dopaminergic diencephalospinal axons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(28):8914-8926
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