Gene

thoc2

ID

ZDB-GENE-030616-54

Name

THO complex 2

Symbol

thoc2 Nomenclature History

Previous Names

Tho2 (1)
fb73e08
fd21d11
si:bz1o18.2
wu:fb73e08
wu:fd21d11

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to enable mRNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to act upstream of or within mRNA processing. Predicted to be located in nucleus. Predicted to be part of THO complex part of transcription export complex. Human ortholog(s) of this gene implicated in X-linked intellectual disability-short stature-overweight syndrome. Orthologous to human THOC2 (THO complex subunit 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With thoc2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
X-linked intellectual disability-short stature-overweight syndrome	Alliance	Intellectual developmental disorder, X-linked syndromic, Kumar type	300957
		Arthrogryposis multiplex congenita 7, X-linked	301127

Associated With thoc2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR021418	THO complex, subunitTHOC2, C-terminal
Domain	IPR021726	THO complex, subunitTHOC2, N-terminal
Domain	IPR032302	THO complex subunit 2, N-terminal domain
Family	IPR040007	THO complex subunit 2

Domain Details Per Protein

Protein	Length	THO complex subunit 2	THO complex subunit 2, N-terminal domain	THO complex, subunitTHOC2, C-terminal	THO complex, subunitTHOC2, N-terminal
UniProtKB:F1R5B5 InterPro	1535
UniProtKB:F1QXF4 InterPro	1560

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	thoc2-202 (1) Ensembl	Ensembl	5,492 nt	Select Tool ZFIN BLAST
mRNA	thoc2-203 (1) Ensembl	Ensembl	5,457 nt	Select Tool ZFIN BLAST
mRNA	thoc2-204 (1) Ensembl	Ensembl	1,063 nt	Select Tool ZFIN BLAST
ncRNA	thoc2-001 (1) Ensembl	Ensembl	5,471 nt	Select Tool ZFIN BLAST
ncRNA	thoc2-002 (1) Ensembl	Ensembl	352 nt	Select Tool ZFIN BLAST
ncRNA	thoc2-005 (1) Ensembl	Ensembl	2,584 nt	Select Tool ZFIN BLAST
ncRNA	thoc2-006 (1) Ensembl	Ensembl	574 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations