ZFIN is now using GRCz12tu for Genomic Data
Gene
cblb
- ID
- ZDB-GENE-030616-417
- Name
- Cbl proto-oncogene B, E3 ubiquitin protein ligase
- Symbol
- cblb Nomenclature History
- Previous Names
-
- si:busm1-25n23.1
- si:busm1-39l02.2
- si:dz25n23.1
- si:dz39l02.2
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable receptor tyrosine kinase binding activity and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of epidermal growth factor receptor signaling pathway and signal transduction. Predicted to act upstream of or within cell surface receptor signaling pathway and regulation of signaling. Predicted to be located in cytoplasm. Predicted to be active in membrane raft and plasma membrane. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; stomach carcinoma; and type 1 diabetes mellitus. Orthologous to human CBLB (Cbl proto-oncogene B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Anelli et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| infantile onset multisystem autoimmune disease 3 | Alliance | Autoimmune disease, multisystem, infantile-onset, 3 | 620430 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017907 | Zinc finger, RING-type, conserved site |
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR003153 | Adaptor protein Cbl, N-terminal helical |
| Domain | IPR014741 | Adaptor protein Cbl, EF hand-like |
| Domain | IPR014742 | Adaptor protein Cbl, SH2-like domain |
| Domain | IPR015940 | Ubiquitin-associated domain |
| Domain | IPR018957 | Zinc finger, C3HC4 RING-type |
| Domain | IPR024159 | Adaptor protein Cbl, PTB domain |
| Family | IPR024162 | Adaptor protein Cbl |
| Homologous_superfamily | IPR011992 | EF-hand domain pair |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR036537 | Adaptor protein Cbl, N-terminal domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Adaptor protein Cbl | Adaptor protein Cbl, EF hand-like | Adaptor protein Cbl, N-terminal domain superfamily | Adaptor protein Cbl, N-terminal helical | Adaptor protein Cbl, PTB domain | Adaptor protein Cbl, SH2-like domain | EF-hand domain pair | SH2 domain superfamily | Ubiquitin-associated domain | Zinc finger, C3HC4 RING-type | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PFD0 | InterPro | 939 | |||||||||||||
| UniProtKB:A0A8M9PAD4 | InterPro | 184 | |||||||||||||
| UniProtKB:F1Q742 | InterPro | 939 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cblb-201
(1)
|
Ensembl | 6,532 nt | ||
| mRNA |
cblb-202
(1)
|
Ensembl | 3,845 nt | ||
| mRNA | ottdart00000001912 (1) | Havana | 2,156 nt | ||
| mRNA | ottdart00000001985 (1) | Havana | 2,047 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers