Gene
ltk
- ID
- ZDB-GENE-030616-115
- Name
- leukocyte receptor tyrosine kinase
- Symbol
- ltk Nomenclature History
- Previous Names
-
- shd(l)
- si:dz107o16.1
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in iridophore differentiation; pigment cell development; and regulation of developmental pigmentation. Acts upstream of or within maintenance of cell number; melanocyte differentiation; and melanocyte migration. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including immature eye; iridoblast; neural crest; notochord; and pigment cell. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to several human genes including LTK (leukocyte receptor tyrosine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 37 figures from 15 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| dtwc3 | Allele with one point mutation | Unknown | Missense | ENU | |
| j9e1 | Allele with one point mutation | Unknown | Unknown | not specified | |
| j9e2 | Allele with one point mutation | Unknown | Unknown | not specified | |
| j9s1 | Allele with one point mutation | Unknown | Missense | spontaneous | |
| sa1500 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9910 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42962 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa45612 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tc205 | unknown | Unknown | Unknown | ENU | |
| te295 | unknown | Unknown | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ltk | (2) | |
| CRISPR2-ltk | (2) | |
| CRISPR3-ltk | (2) | |
| CRISPR4-ltk | (2) | |
| CRISPR5-ltk | (2) | |
| CRISPR6-ltk | (2) | |
| CRISPR7-ltk | (2) | |
| CRISPR8-ltk | (2) | |
| CRISPR9-ltk | (2) | |
| CRISPR10-ltk | Mo et al., 2017 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Neuroblastoma, susceptibility to, 3} | 613014 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR002011 | Tyrosine-protein kinase, receptor class II, conserved site |
| Conserved_site | IPR023415 | Low-density lipoprotein (LDL) receptor class A, conserved site |
| Domain | IPR000719 | Protein kinase domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | ALK/LTK-like, glycine-rich domain | Concanavalin A-like lectin/glucanase domain superfamily | LDL receptor-like superfamily | Low-density lipoprotein (LDL) receptor class A, conserved site | Low-density lipoprotein (LDL) receptor class A repeat | MAM domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, receptor class II, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QVU0 | InterPro | 1530 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-254C11 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-170L10 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-107O16 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001006660 (1) | 4593 nt | ||
| Genomic | GenBank:BX548068 (1) | 177449 nt | ||
| Polypeptide | UniProtKB:F1QVU0 (1) | 1530 aa |
- Eom, D.S., Patterson, L.B., Bostic, R.R., Parichy, D.M. (2021) Immunoglobulin superfamily receptor junctional adhesion molecule 3 (Jam3) requirement for melanophore survival and patterning during formation of zebrafish stripes. Developmental Biology. 476:314-327
- McCluskey, B.M., Liang, Y., Lewis, V.M., Patterson, L.B., Parichy, D.M. (2021) Pigment pattern morphospace of Danio fishes: evolutionary diversification and mutational effects. Biology Open. 10(9):
- McCluskey, B.M., Uji, S., Mancusi, J.L., Postlethwait, J.H., Parichy, D.M. (2021) A complex genetic architecture in zebrafish relatives Danio quagga and D. kyathit underlies development of stripes and spots. PLoS Genetics. 17:e1009364
- Petratou, K., Spencer, S.A., Kelsh, R.N., Lister, J.A. (2021) The MITF paralog tfec is required in neural crest development for fate specification of the iridophore lineage from a multipotent pigment cell progenitor. PLoS One. 16:e0244794
- McGuirl, M.R., Volkening, A., Sandstede, B. (2020) Topological data analysis of zebrafish patterns. Proceedings of the National Academy of Sciences of the United States of America. 117(10):5113-5124
- Volkening, A., Abbott, M.R., Chandra, N., Dubois, B., Lim, F., Sexton, D., Sandstede, B. (2020) Modeling Stripe Formation on Growing Zebrafish Tailfins. Bulletin of mathematical biology. 82:56
- Camargo-Sosa, K., Colanesi, S., Müller, J., Schulte-Merker, S., Stemple, D., Patton, E.E., Kelsh, R.N. (2019) Endothelin receptor Aa regulates proliferation and differentiation of Erb-dependent pigment progenitors in zebrafish. PLoS Genetics. 15:e1007941
- Eskova, A., Frohnhöfer, H.G., Nüsslein-Volhard, C., Irion, U. (2019) Galanin Signaling in the Brain Regulates Color Pattern Formation in Zebrafish. Current biology : CB. 30(2):298-303.e3
- Lewis, V.M., Saunders, L.M., Larson, T.A., Bain, E.J., Sturiale, S.L., Gur, D., Chowdhury, S., Flynn, J.D., Allen, M.C., Deheyn, D.D., Lee, J.C., Simon, J.A., Lippincott-Schwartz, J., Raible, D.W., Parichy, D.M. (2019) Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores. Proceedings of the National Academy of Sciences of the United States of America. 116(24):11806-11811
- Fadeev, A., Mendoza-Garcia, P., Irion, U., Guan, J., Pfeifer, K., Wiessner, S., Serluca, F., Singh, A.P., Nüsslein-Volhard, C., Palmer, R.H. (2018) ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells. Proceedings of the National Academy of Sciences of the United States of America. 115(4):E630-E638
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