Gene
uacab
- ID
- ZDB-GENE-030521-32
- Name
- uveal autoantigen with coiled-coil domains and ankyrin repeats b
- Symbol
- uacab Nomenclature History
- Previous Names
-
- fj33f05
- sb:cb472
- wu:fj33f05
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to be involved in intrinsic apoptotic signaling pathway; negative regulation of inflammatory response; and negative regulation of non-canonical NF-kappaB signal transduction. Predicted to be located in cytoskeleton. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including gut; hindbrain neural plate; midbrain neural keel; musculature system; and nervous system. Orthologous to human UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb472 (19 images)
- IMAGE:7158429 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa7072 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa7073 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9033 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10010 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10140 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11696 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15099 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20990 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31580 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40940 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily |
|---|---|---|---|---|
| UniProtKB:F1QM39 | InterPro | 1371 | ||
| UniProtKB:A0A286Y884 | InterPro | 1375 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-106F13 | ZFIN Curated Data | |
| Encodes | EST | cb472 | Thisse et al., 2001 | |
| Encodes | EST | fj33f05 | ||
| Encodes | EST | IMAGE:7158429 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005168952 (1) | 5895 nt | ||
| Genomic | GenBank:BX511006 (2) | 220514 nt | ||
| Polypeptide | UniProtKB:A0A286Y884 (1) | 1375 aa |
- Vejnar, C.E., Abdelmessih, M., Takacs, C., Yartseva, V., Oikonomou, P., Christiano, R., Stoeckius, M., Lau, S., Lee, M., Beaudoin, J.D., Musaev, D., Darwich-Codore, H., Walther, T., Tavazoie, S., Cifuentes, D., Giraldez, A. (2019) Genome wide analysis of 3'-UTR sequence elements and proteins regulating mRNA stability during maternal-to-zygotic transition in zebrafish. Genome research. 29(7):1100-1114
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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