Gene
mbpb
- ID
- ZDB-GENE-030429-21
- Name
- myelin basic protein b
- Symbol
- mbpb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of myelin sheath. Located in myelin sheath and plasma membrane. Is expressed in nervous system and polster. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human MBP (myelin basic protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb183 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6406 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR000548 | Myelin basic protein |
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Domain Details Per Protein
| Protein | Length | Myelin basic protein |
|---|---|---|
|
UniProtKB:A0A8M2B444
|
135 | |
|
UniProtKB:E7EYA2
|
133 | |
|
UniProtKB:F8W4C1
|
121 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-198O19 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-241K19 | ZFIN Curated Data | |
| Encodes | EST | cb183 | Thisse et al., 2001 | |
| Encodes | EST | fb71b08 | ||
| Encodes | EST | IMAGE:3815793 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001271459 (1) | 2003 nt | ||
| Genomic | GenBank:AL845419 (2) | 176379 nt | ||
| Polypeptide | UniProtKB:A0A8M2B444 (1) | 135 aa |
- Hu, M., Bodnar, B., Zhang, Y., Xie, F., Li, F., Li, S., Zhao, J., Zhao, R., Gedupoori, N., Mo, Y., Lin, L., Li, X., Meng, W., Yang, X., Wang, H., Barbe, M.F., Srinivasan, S., Bethea, J.R., Mo, X., Xu, H., Hu, W. (2023) Defective neurite elongation and branching in Nibp/Trappc9 deficient zebrafish and mice. International journal of biological sciences. 19:322632483226-3248
- Zhang, T., Alonzo, I., Stubben, C., Geng, Y., Herdman, C., Chandler, N., Doane, K.P., Pluimer, B.R., Trauger, S.A., Peterson, R.T. (2023) A zebrafish model of Combined Saposin Deficiency identifies acid sphingomyelinase as a potential therapeutic target. Disease models & mechanisms. 16(7):
- Xing, L., Chai, R., Wang, J., Lin, J., Li, H., Wang, Y., Lai, B., Sun, J., Chen, G. (2022) Expression of myelin transcription factor 1 and lamin B receptor mediate neural progenitor fate transition in the zebrafish spinal cord pMN domain. The Journal of biological chemistry. 298(10):102452
- Blanco-Sánchez, B., Clément, A., Stednitz, S.J., Kyle, J., Peirce, J.L., McFadden, M., Wegner, J., Phillips, J.B., Macnamara, E., Huang, Y., Adams, D.R., Toro, C., Gahl, W.A., Malicdan, M.C.V., Tifft, C.J., Zink, E.M., Bloodsworth, K.J., Stratton, K.G., Undiagnosed Diseases Network, Koeller, D.M., Metz, T.O., Washbourne, P., Westerfield, M. (2020) yippee like 3 (ypel3) is a novel gene required for myelinating and perineurial glia development. PLoS Genetics. 16:e1008841
- Yatsuka, H., Hada, K., Shiraishi, H., Umeda, R., Morisaki, I., Urushibata, H., Shimizu, N., Sebastian, W.A., Hikida, T., Ishitani, T., Hanada, R., Shimada, T., Kimoto, K., Kubota, T., Hanada, T. (2020) Exosc2 deficiency leads to developmental disorders by causing a nucleotide pool imbalance in zebrafish. Biochemical and Biophysical Research Communications. 533:1470-1476
- Nagarajan, B., Harder, A., Japp, A., Häberlein, F., Mingardo, E., Kleinert, H., Yilmaz, Ö., Zoons, A., Rau, B., Christ, A., Kubitscheck, U., Eiberger, B., Sandhoff, R., Eckhardt, M., Hartmann, D., Odermatt, B. (2019) CNS myelin protein 36K regulates oligodendrocyte differentiation through Notch. Glia. 68(3):509-527
- Walter, K.M., Dach, K., Hayakawa, K., Giersiefer, S., Heuer, H., Lein, P.J., Fritsche, E. (2019) Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison. PLoS One. 14:e0221230
- Torvund-Jensen, J., Steengaard, J., Askebjerg, L.B., Kjaer-Sorensen, K., Laursen, L.S. (2018) The 3'UTRs of Myelin Basic Protein mRNAs Regulate Transport, Local Translation and Sensitivity to Neuronal Activity in Zebrafish. Frontiers in molecular neuroscience. 11:185
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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