Gene

zc3h3

ID

ZDB-GENE-030131-9399

Name

zinc finger CCCH-type containing 3

Symbol

zc3h3 Nomenclature History

Previous Names

fj68a07
wu:fj68a07

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to enable metal ion binding activity. Predicted to be active in nucleus. Orthologous to human ZC3H3 (zinc finger CCCH-type containing 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7157405 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa20730	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa20731	Allele with one point mutation	Unknown	Splice Site	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With zc3h3 Human Ortholog

No data available

Associated With zc3h3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000571	Zinc finger, CCCH-type
Homologous_superfamily	IPR036855	Zinc finger, CCCH-type superfamily

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Domain Details Per Protein

Protein	Length	Zinc finger, CCCH-type	Zinc finger, CCCH-type superfamily
UniProtKB:E7FH07 InterPro	929

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Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 6

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	zc3h3-201 (1) Ensembl	Ensembl	3,528 nt	Select Tool ZFIN BLAST
mRNA	zc3h3-202 (1) Ensembl	Ensembl	753 nt	Select Tool ZFIN BLAST
ncRNA	zc3h3-002 (1) Ensembl	Ensembl	795 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH73-269F15	CU694370	ZFIN Curated Data
Contained in	BAC	DKEY-46I24	CR848029	ZFIN Curated Data
Encodes	EST	fj68a07	AW076513
Encodes	EST	IMAGE:7157405	CK693032	Thisse et al., 2004

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_684588 (1)	3226 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR848029 (1)	238923 nt	Select Tool MegaBLAST
Polypeptide	UniProtKB:E7FH07 (1)	929 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	ZC3H3	8	Ensembl:ENSG00000014164 Gene:23144 OMIM:618640 HGNC:28972	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)
Mouse	Zc3h3	15	Ensembl:ENSMUSG00000075600 MGI:2663721 Gene:223642	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

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