Gene

doc2b

ID

ZDB-GENE-090615-1

Name

double C2-like domains, beta

Symbol

doc2b Nomenclature History

Previous Names

WITHDRAWN: wu:fb11f01
wu:fb11f01

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable calcium ion binding activity and calcium-dependent phospholipid binding activity. Predicted to be involved in exocytosis; regulation of calcium ion-dependent exocytosis; and spontaneous neurotransmitter secretion. Predicted to act upstream of or within chemical synaptic transmission and intracellular protein transport. Predicted to be located in membrane. Predicted to be active in synapse. Orthologous to human DOC2B (double C2 domain beta).

Genome Resources

Note

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With doc2b Human Ortholog

No data available

Associated With doc2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000008	C2 domain
Domain	IPR001565	Synaptotagmin
Domain	IPR010911	Rab-binding domain
Domain	IPR017455	Zinc finger, FYVE-related
Domain	IPR041282	FYVE-type zinc finger
Domain	IPR047022	Rabphilin/Doc2, first C2 domain
Family	IPR014638	Double C2 protein, alpha/beta/gamma
Family	IPR043566	Rabphilin/Doc2/Noc2
Homologous_superfamily	IPR011011	Zinc finger, FYVE/PHD-type
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR035892	C2 domain superfamily

Domain Details Per Protein

Protein	Length	C2 domain	C2 domain superfamily	Double C2 protein, alpha/beta/gamma	FYVE-type zinc finger	Rab-binding domain	Rabphilin/Doc2, first C2 domain	Rabphilin/Doc2/Noc2	Synaptotagmin	Zinc finger, FYVE/PHD-type	Zinc finger, FYVE-related	Zinc finger, RING/FYVE/PHD-type
UniProtKB:A0A8M3B9Z3 InterPro	593
UniProtKB:A0A8M3ASV5 InterPro	396
UniProtKB:A0A2R8QNT0 InterPro	640
UniProtKB:A0A8M6YYK0 InterPro	648

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	doc2b-201 (1) Ensembl	Ensembl	773 nt	Select Tool ZFIN BLAST
mRNA	doc2b-202 (1) Ensembl	Ensembl	2,080 nt	Select Tool ZFIN BLAST
mRNA	doc2b-203 (1) Ensembl	Ensembl	2,306 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations