ZFIN is now using GRCz12tu for Genomic Data
Gene
arhgef10
- ID
- ZDB-GENE-030131-6210
- Name
- Rho guanine nucleotide exchange factor (GEF) 10
- Symbol
- arhgef10 Nomenclature History
- Previous Names
-
- wu:fi38h08
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in actin cytoskeleton organization; mitotic spindle assembly; and positive regulation of stress fiber assembly. Predicted to be active in centrosome and cytoplasm. Orthologous to human ARHGEF10 (Rho guanine nucleotide exchange factor 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Zhang et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Zhang et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Slowed nerve conduction velocity, AD | 608236 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000219 | Dbl homology domain |
| Family | IPR039919 | Rho guanine nucleotide exchange factor 10/17 |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Dbl homology (DH) domain superfamily | Dbl homology domain | Rho guanine nucleotide exchange factor 10/17 | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AJ04 | InterPro | 1412 | |||||
| UniProtKB:A0A8M9Q2J2 | InterPro | 1411 | |||||
| UniProtKB:A0A8M9PCU5 | InterPro | 1373 | |||||
| UniProtKB:A0A8M9PLF3 | InterPro | 1412 | |||||
| UniProtKB:A0A8M3B2F6 | InterPro | 1373 | |||||
| UniProtKB:A0AB32TNW3 | InterPro | 1314 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arhgef10-201
(1)
|
Ensembl | 3,720 nt | ||
| mRNA |
arhgef10-202
(1)
|
Ensembl | 4,004 nt | ||
| ncRNA |
arhgef10-002
(1)
|
Ensembl | 780 nt | ||
| ncRNA |
arhgef10-003
(1)
|
Ensembl | 296 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers