Gene

zbtb11

ID

ZDB-GENE-030131-5055

Name

zinc finger and BTB domain containing 11

Symbol

zbtb11 Nomenclature History

Previous Names

man
marsanne (1)
mne
si:dkey-98p3.1
si:dkeyp-116g9.2
wu:fc06h02
wu:fe36e08 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have metal ion binding activity and nucleic acid binding activity. Involved in neutrophil differentiation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Is expressed in head; intermediate cell mass of mesoderm; and nervous system. Orthologous to human ZBTB11 (zinc finger and BTB domain containing 11).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Keightley et al., 2017

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Keightley et al., 2017
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With zbtb11 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive intellectual developmental disorder 69	Alliance	Intellectual developmental disorder, autosomal recessive 69	618383

Associated With zbtb11 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000210	BTB/POZ domain
Domain	IPR013087	Zinc finger C2H2-type
Domain	IPR041588	Integrase zinc-binding domain
Domain	IPR048060	Zinc finger and BTB domain-containing protein 11, BTB/POZ domain
Homologous_superfamily	IPR011333	SKP1/BTB/POZ domain superfamily
Homologous_superfamily	IPR036236	Zinc finger C2H2 superfamily