Gene
esf1
- ID
- ZDB-GENE-030131-4917
- Name
- ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
- Symbol
- esf1 Nomenclature History
- Previous Names
-
- fe06g12
- im:7138472
- wu:fe06g12
- zgc:66241
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity. Acts upstream of or within neural crest cell development; pharyngeal system development; and rRNA processing. Predicted to be located in nucleolus. Is expressed in several structures, including digestive system; head; immature eye; midbrain neural rod; and pectoral fin bud. Orthologous to human ESF1 (ESF1 nucleolar pre-rRNA processing protein homolog).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7138472 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Chen et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ouc3 | Allele with one deletion | Exon 6 | Premature Stop | CRISPR | |
| ouc4 | Allele with one deletion | Exon 6 | Premature Stop | CRISPR | |
| ouc5 | Allele with one insertion | Exon 6 | Premature Stop | CRISPR | |
| sa19593 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38297 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | NUC153 | Nucleotide-binding alpha-beta plait domain superfamily | Pre-rRNA-processing protein Esf1 |
|---|---|---|---|---|
|
UniProtKB:B8JKQ1
|
757 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-210M15 | ZFIN Curated Data | |
| Encodes | EST | fe06g12 | ||
| Encodes | EST | IMAGE:7138472 | Thisse et al., 2004 | |
| Has Artifact | cDNA | WITHDRAWN:MGC:66241 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199745 (1) | 2515 nt | ||
| Genomic | GenBank:CR762436 (1) | 177448 nt | ||
| Polypeptide | UniProtKB:B8JKQ1 (1) | 757 aa |
- Wu, N., Liu, B., Du, H., Zhao, S., Li, Y., Cheng, X., Wang, S., Lin, J., Zhou, J., Deciphering Disorders Involving Scoliosis and COmorbidities (DISCO) study, Qiu, G., Wu, Z., Zhang, J. (2019) The Progress of CRISPR/Cas9-Mediated Gene Editing in Generating Mouse/Zebrafish Models of Human Skeletal Diseases. Computational and structural biotechnology journal. 17:954-962
- Chen, J.Y., Tan, X., Wang, Z.H., Liu, Y.Z., Zhou, J.F., Rong, X.Z., Lu, L., Li, Y. (2018) The Ribosome Biogenesis Protein Esf1 is Essential for Pharyngeal Cartilage Formation in zebrafish. The FEBS journal. 285(18):3464-3484
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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