ZFIN is now using GRCz12tu for Genomic Data
Gene
plekhg4
- ID
- ZDB-GENE-030131-4824
- Name
- pleckstrin homology domain containing, family G (with RhoGef domain) member 4
- Symbol
- plekhg4 Nomenclature History
- Previous Names
-
- id:ibd5125
- wu:fd99e06
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Is expressed in several structures, including brain; midbrain neural keel; presumptive diencephalon; segmental plate; and ventricular zone. Orthologous to human PLEKHG4 (pleckstrin homology and RhoGEF domain containing G4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7154857 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000219 | Dbl homology domain |
| Domain | IPR001251 | CRAL-TRIO lipid binding domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR055251 | SOS1/NGEF-like, PH domain |
| Family | IPR052231 | Rho GEF and signaling-related domain-containing protein |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
| Homologous_superfamily | IPR036865 | CRAL-TRIO lipid binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | CRAL-TRIO lipid binding domain | CRAL-TRIO lipid binding domain superfamily | Dbl homology (DH) domain superfamily | Dbl homology domain | PH-like domain superfamily | Pleckstrin homology domain | Rho GEF and signaling-related domain-containing protein | SOS1/NGEF-like, PH domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PS08 | InterPro | 1110 | ||||||||
| UniProtKB:E7FEK1 | InterPro | 2630 | ||||||||
| UniProtKB:A0A8M9QHX1 | InterPro | 1625 | ||||||||
| UniProtKB:A0A8M3B495 | InterPro | 2619 | ||||||||
| UniProtKB:A0A8M9Q2K4 | InterPro | 1099 | ||||||||
| UniProtKB:A0A8M2BGC7 | InterPro | 837 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
plekhg4-201
(1)
|
Ensembl | 8,998 nt | ||
| mRNA |
plekhg4-202
(1)
|
Ensembl | 8,626 nt | ||
| mRNA |
plekhg4-203
(1)
|
Ensembl | 8,704 nt | ||
| mRNA |
plekhg4-204
(1)
|
Ensembl | 8,587 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance