Gene
rpl27
- ID
- ZDB-GENE-030131-4343
- Name
- ribosomal protein L27
- Symbol
- rpl27 Nomenclature History
- Previous Names
-
- fc93a08
- wu:fc93a08
- zgc:56171 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of ribosome. Acts upstream of or within erythrocyte differentiation. Predicted to be located in cytoplasmic side of rough endoplasmic reticulum membrane. Predicted to be part of cytosolic large ribosomal subunit. Is expressed in endodermal cell; intestine; liver; and pancreas. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 16. Orthologous to human RPL27 (ribosomal protein L27).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56171 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Wang et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Diamond-Blackfan anemia 16 | Alliance | ?Diamond-Blackfan anemia 16 | 617408 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018262 | Large ribosomal subunit protein eL27, conserved site |
| Domain | IPR005824 | KOW |
| Domain | IPR041991 | Large ribosomal subunit protein eL27, KOW domain |
| Family | IPR001141 | Large ribosomal subunit protein eL27 |
| Homologous_superfamily | IPR008991 | Translation protein SH3-like domain superfamily |
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Domain Details Per Protein
| Protein | Length | KOW | Large ribosomal subunit protein eL27 | Large ribosomal subunit protein eL27, conserved site | Large ribosomal subunit protein eL27, KOW domain | Large ribosomal subunit protein eL27 superfamily | Translation protein SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZV82
|
136 | ||||||
|
UniProtKB:B2GP62
|
136 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-151M15 | ZFIN Curated Data | |
| Encodes | EST | fc93a08 | ||
| Encodes | cDNA | MGC:56171 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191398 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199724 (1) | 510 nt | ||
| Genomic | GenBank:BX901883 (1) | 241961 nt | ||
| Polypeptide | UniProtKB:B2GP62 (1) | 136 aa |
- Cheung, C.T., Nguyen, T.V., Le Cam, A., Patinote, A., Journot, L., Reynes, C., Bobe, J. (2019) What makes a bad egg? Egg transcriptome reveals dysregulation of translational machinery and novel fertility genes important for fertilization. BMC Genomics. 20:584
- Kwon, O.K., Kim, S.J., Lee, S. (2018) First profiling of lysine crotonylation of myofilament proteins and ribosomal proteins in zebrafish embryos. Scientific Reports. 8:3652
- Zhang, Y., Su, G., Li, M., Li, S., Wang, Q., Zhu, G., Letcher, R.J., Liu, C. (2018) Chemical and biological transfer: Which one is responsible for the maternal transfer toxicity of tris(1,3-dichloro-2-propyl) phosphate in zebrafish?. Environmental pollution (Barking, Essex : 1987). 243:1376-1382
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Cai, Y., Zhang, C., Hao, L., Chen, J., Xie, P., Chen, Z. (2016) Systematic identification of seven ribosomal protein genes in bighead carp and their expression in response to microcystin-LR. The Journal of Toxicological Sciences. 41:293-302
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wang, R., Yoshida, K., Toki, T., Sawada, T., Uechi, T., Okuno, Y., Sato-Otsubo, A., Kudo, K., Kamimaki, I., Kanezaki, R., Shiraishi, Y., Chiba, K., Tanaka, H., Terui, K., Sato, T., Iribe, Y., Ohga, S., Kuramitsu, M., Hamaguchi, I., Ohara, A., Hara, J., Goi, K., Matsubara, K., Koike, K., Ishiguro, A., Okamoto, Y., Watanabe, K., Kanno, H., Kojima, S., Miyano, S., Kenmochi, N., Ogawa, S., Ito, E. (2015) Loss of function mutations in RPL27 and RPS27 identified by whole-exome sequencing in Diamond-Blackfan anaemia. British journal of haematology. 168(6):854-64
- Tseng, L.C., Zhang, C., Cheng, C.M., Xu, H., Hsu, C.H., Jiang, Y.J. (2014) New classes of mind bomb-interacting proteins identified from yeast two-hybrid screens. PLoS One. 9:e93394
- Provost, E., Weier, C.A., and Leach, S.D. (2013) Multiple ribosomal proteins are expressed at high levels in developing zebrafish endoderm and are required for normal exocrine pancreas development. Zebrafish. 10(2):161-169
- Linney, E., Dobbs-McAuliffe, B., Sajadi, H., and Malek, R.L. (2004) Microarray gene expression profiling during the segmentation phase of zebrafish development. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 138(3):351-362
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