Gene

usp7

ID

ZDB-GENE-030131-3656

Name

ubiquitin specific peptidase 7 (herpes virus-associated)

Symbol

usp7 Nomenclature History

Previous Names

fc48f04
wu:fc48f04

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have cysteine-type endopeptidase activity; thiol-dependent ubiquitin-specific protease activity; and transcription factor binding activity. Involved in cranial skeletal system development. Predicted to localize to cytosol and nucleus. Orthologous to human USP7 (ubiquitin specific peptidase 7).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7155505 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With usp7 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Hao-Fountain syndrome	616863

Associated With usp7 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018200	Ubiquitin specific protease, conserved site
Domain	IPR001394	Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Domain	IPR002083	MATH/TRAF domain
Domain	IPR024729	Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain
Domain	IPR028889	Ubiquitin specific protease domain
Domain	IPR029346	Ubiquitin carboxyl-terminal hydrolase, C-terminal
Homologous_superfamily	IPR008974	TRAF-like
Homologous_superfamily	IPR038765	Papain-like cysteine peptidase superfamily

Domain Details Per Protein

Protein	Length	MATH/TRAF domain	Papain-like cysteine peptidase superfamily	Peptidase C19, ubiquitin carboxyl-terminal hydrolase	TRAF-like	Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain	Ubiquitin carboxyl-terminal hydrolase, C-terminal	Ubiquitin specific protease, conserved site	Ubiquitin specific protease domain
UniProtKB:A0A8M9Q474 InterPro	1086
UniProtKB:A0A8M3AQW7 InterPro	1123
UniProtKB:A0A8M3B0Y8 InterPro	1096
UniProtKB:A0A8M3B8A7 InterPro	1130
UniProtKB:I3ISS5 InterPro	1103
UniProtKB:F1QUS9 InterPro	1110

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	usp7-202 (1) Ensembl	Havana	5721 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations