Gene
dicer1
- ID
- ZDB-GENE-030131-3445
- Name
- dicer 1, ribonuclease type III
- Symbol
- dicer1 Nomenclature History
- Previous Names
-
- fc39d11
- fc74b05
- wu:fc39d11
- wu:fc74b05
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Exhibits pre-miRNA binding activity. Involved in gene silencing by miRNA and nervous system development. Predicted to localize to several cellular components, including RISC complex; RISC-loading complex; and nucleus. Human ortholog(s) of this gene implicated in multinodular goiter and pleuropulmonary blastoma. Is expressed in several structures, including heart; integument; liver; nervous system; and pleuroperitoneal region. Orthologous to human DICER1 (dicer 1, ribonuclease III).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| DICER1 syndrome | Alliance | Pleuropulmonary blastoma | 601200 |
| multinodular goiter | Alliance | Goiter, multinodular 1, with or without Sertoli-Leydig cell tumors | 138800 |
| GLOW syndrome, somatic mosaic | 618272 | ||
| Rhabdomyosarcoma, embryonal, 2 | 180295 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000999 | Ribonuclease III domain |
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR003100 | PAZ domain |
| Domain | IPR005034 | Dicer dimerisation domain |
| Domain | IPR011545 | DEAD/DEAH box helicase domain |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR014720 | Double-stranded RNA-binding domain |
| Domain | IPR044441 | Dicer, double-stranded RNA-binding domain |
| Domain | IPR048512 | Dicer, platform domain |
| Domain | IPR048513 | Dicer, partner-binding domain |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036085 | PAZ domain superfamily |
| Homologous_superfamily | IPR036389 | Ribonuclease III, endonuclease domain superfamily |
| Homologous_superfamily | IPR038248 | Dicer dimerisation domain superfamily |
Domain Details Per Protein
| Protein | Length | DEAD/DEAH box helicase domain | Dicer dimerisation domain | Dicer dimerisation domain superfamily | Dicer, double-stranded RNA-binding domain | Dicer, partner-binding domain | Dicer, platform domain | Double-stranded RNA-binding domain | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | PAZ domain | PAZ domain superfamily | P-loop containing nucleoside triphosphate hydrolase | Ribonuclease III domain | Ribonuclease III, endonuclease domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6TV19
|
1865 | ||||||||||||||
|
UniProtKB:A0A8M9PNL3
|
1865 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dicer1-201
(1)
|
Ensembl | 9,598 nt | ||
| mRNA |
dicer1-202
(1)
|
Ensembl | 6,123 nt |
Interactions and Pathways
No data available
Plasmids