Gene
styk1b
- ID
- ZDB-GENE-030131-3435
- Name
- serine/threonine/tyrosine kinase 1b
- Symbol
- styk1b Nomenclature History
- Previous Names
-
- styk1
- styk1c (1)
- wu:fc39b09
- wu:fe11d05
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human STYK1 (serine/threonine/tyrosine kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Challa et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-styk1b | Zhou et al., 2019 | |
| CRISPR2-styk1b | Zhou et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|
| UniProtKB:E9QCV8 | InterPro | 447 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
styk1b-201
(1)
|
Ensembl | 2,117 nt | ||
| mRNA |
styk1b-202
(1)
|
Ensembl | 4,971 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-40M6 | ZFIN Curated Data | |
| Contains | SNP | rs3728469 | ZFIN Curated Data | |
| Contains | SNP | rs3728470 | ZFIN Curated Data | |
| Contains | SNP | rs3728471 | ZFIN Curated Data | |
| Encodes | EST | fc39b09 | ||
| Encodes | EST | fe11d05 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001305565 (1) | 2118 nt | ||
| Genomic | GenBank:CR854927 (1) | 217399 nt | ||
| Polypeptide | UniProtKB:E9QCV8 (1) | 447 aa |
- Zhou, C., Qian, X., Hu, M., Zhang, R., Liu, N., Huang, Y., Yang, J., Zhang, J., Bai, H., Yang, Y., Wang, Y., Ali, D., Michalak, M., Chen, X.Z., Tang, J. (2019) STYK1 promotes autophagy through enhancing the assembly of autophagy-specific class III phosphatidylinositol 3-kinase complex I. Autophagy. 16(10):1786-1806
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wang, Y.F., Yan, J.J., Tseng, Y.C., Chen, R.D., Hwang, P.P. (2015) Molecular Physiology of an Extra-renal Cl(-) Uptake Mechanism for Body Fluid Cl(-) Homeostasis. International journal of biological sciences. 11:1190-203
- Challa, A.K., and Chatti, K. (2013) Conservation and Early Expression of Zebrafish Tyrosine Kinases Support the Utility of Zebrafish as a Model for Tyrosine Kinase Biology. Zebrafish. 10(3):264-74
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
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