Gene
wdr81
- ID
- ZDB-GENE-030131-3389
- Name
- WD repeat domain 81
- Symbol
- wdr81 Nomenclature History
- Previous Names
-
- fc37g06
- wu:fc37g06
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to have phosphatidylinositol 3-kinase regulator activity. Predicted to be involved in aggrephagy; early endosome to late endosome transport; and ubiquitin-dependent protein catabolic process. Predicted to localize to autophagosome membrane; cytosol; and endosome membrane. Human ortholog(s) of this gene implicated in cerebellar ataxia, mental retardation and dysequlibrium syndrome and hydrocephalus. Is expressed in several structures, including heart; liver; nervous system; optic vesicle; and pleuroperitoneal region. Orthologous to human WDR81 (WD repeat domain 81).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cerebellar ataxia, mental retardation and dysequlibrium syndrome | Alliance | Cerebellar ataxia, impaired intellectual development, and dysquilibrium syndrome 2 | 610185 |
| Hydrocephalus, congenital, 3, with brain anomalies | 617967 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | BEACH domain | BEACH domain superfamily | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:E7FEV0
|
2065 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance