Gene
tle2a
- ID
- ZDB-GENE-030131-2826
- Name
- TLE family member 2, transcriptional corepressor a
- Symbol
- tle2a Nomenclature History
- Previous Names
-
- tle2 (1)
- fc18h03
- sb:eu1034
- sb:eu408
- si:ch211-81i17.1
- wu:fb96a10
- wu:fc18h03
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in oocyte; telencephalon; and unfertilized egg. Orthologous to several human genes including TLE7 (TLE family member 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Domain | IPR005617 | Groucho/TLE, N-terminal Q-rich domain |
| Family | IPR009146 | Groucho/transducin-like enhancer |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Groucho/TLE, N-terminal Q-rich domain | Groucho/transducin-like enhancer | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:B3DJR5 | InterPro | 811 | ||||||
| UniProtKB:A0A8M2BI83 | InterPro | 790 | ||||||
| UniProtKB:A0A8M2BHU5 | InterPro | 801 | ||||||
| UniProtKB:A0A8M3B5J1 | InterPro | 786 | ||||||
| UniProtKB:A0A8M2BHT3 | InterPro | 796 | ||||||
| UniProtKB:A0AB32TCP7 | InterPro | 790 | ||||||
| UniProtKB:A0AB32TD32 | InterPro | 775 | ||||||
| UniProtKB:A0AB32TGL0 | InterPro | 801 |
Interactions and Pathways
No data available
Plasmids
No data available