Gene
ndnf
- ID
- ZDB-GENE-030131-207
- Name
- neuron-derived neurotrophic factor
- Symbol
- ndnf Nomenclature History
- Previous Names
-
- wu:fb16h09
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Involved in gonadotrophin-releasing hormone neuronal migration to the hypothalamus. Acts upstream of or within embryonic neurocranium morphogenesis. Predicted to be located in extracellular region. Is expressed in central nervous system; cranial ganglion; hypochord; somite; and stomodeum. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism. Orthologous to human NDNF (neuron derived neurotrophic factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Melvin et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Hypogonadotropic hypogonadism 25 with anosmia | 618841 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR045805 | Protein NDNF, C-terminal |
| Domain | IPR055271 | Neuron-derived neurotrophic factor, first Fn(III) domain |
| Domain | IPR056225 | Neuron-derived neurotrophic factor, N-terminal domain |
| Family | IPR019326 | Protein NDNF |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | Neuron-derived neurotrophic factor, first Fn(III) domain | Neuron-derived neurotrophic factor, N-terminal domain | Protein NDNF | Protein NDNF, C-terminal |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB13A9V7 | InterPro | 574 | |||||||
| UniProtKB:F1QPX0 | InterPro | 574 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available