Gene
fignl1
- ID
- ZDB-GENE-030131-1862
- Name
- fidgetin-like 1
- Symbol
- fignl1 Nomenclature History
- Previous Names
-
- fb82h05
- wu:fb82h05 (1)
- wu:fj99a11
- zgc:193664
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Enables protein-macromolecule adaptor activity. Acts upstream of or within microtubule cytoskeleton organization; motor neuron axon guidance; and regulation of retrograde axon cargo transport. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including nervous system; solid lens vesicle; swim bladder bud; tail bud; and vertical myoseptum. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human FIGNL1 (fidgetin like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR003960 | ATPase, AAA-type, conserved site |
Domain | IPR003593 | AAA+ ATPase domain |
Domain | IPR003959 | ATPase, AAA-type, core |
Domain | IPR015415 | Spastin/Vps4, C-terminal |
Domain | IPR041569 | AAA ATPase, AAA+ lid domain |
Domain | IPR047858 | Fidgetin-like 1, ATPase domain |
Family | IPR050304 | Microtubule-severing AAA ATPase |
Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
Protein | Additional Resources | Length | AAA ATPase, AAA+ lid domain | AAA+ ATPase domain | ATPase, AAA-type, conserved site | ATPase, AAA-type, core | Fidgetin-like 1, ATPase domain | Microtubule-severing AAA ATPase | P-loop containing nucleoside triphosphate hydrolase | Spastin/Vps4, C-terminal |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:B3DGU1 | InterPro | 661 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
fignl1-201
(1)
|
Ensembl | 2,055 nt | ||
mRNA |
fignl1-202
(1)
|
Ensembl | 2,116 nt |
Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-fignl1 | polyclonal | Rabbit |
|
2 |
Plasmids
No data available