Gene
asb12a
- ID
- ZDB-GENE-030131-1647
- Name
- ankyrin repeat and SOCS box-containing 12a
- Symbol
- asb12a Nomenclature History
- Previous Names
-
- asb12
- wu:fb77b07
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within intracellular signal transduction. Predicted to be part of ubiquitin ligase complex. Is expressed in female organism. Orthologous to human ASB12 (ankyrin repeat and SOCS box containing 12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu2422 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa26453 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | SOCS box domain | SOCS box-like domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:A2CEZ8
|
305 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
asb12a-201
(1)
|
Ensembl | 1,583 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-286F3 | ZFIN Curated Data | |
| Encodes | EST | eu2422 | Thisse et al., 2005 | |
| Encodes | EST | fb77b07 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001126376 (1) | 1584 nt | ||
| Genomic | GenBank:CR812469 (1) | 162086 nt | ||
| Polypeptide | UniProtKB:A2CEZ8 (1) | 305 aa |
- Yang, S., Xu, X., Zhang, A., Wang, Y., Ji, G., Sun, C., Li, H. (2023) The evolution and immunomodulatory role of Zc3h12 proteins in zebrafish (Danio rerio). International journal of biological macromolecules. 239:124214
- Newman, M., Hin, N., Pederson, S., Lardelli, M. (2019) Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Molecular brain. 12:43
- Roberto, V.P., Tiago, D.M., Gautvik, K., Cancela, M.L. (2015) Evidence for the conservation of miR-223 in zebrafish (Danio rerio): Implications for function. Gene. 566(1):54-62
- Castro, L.F., Gonçalves, O., Mazan, S., Tay, B.H., Venkatesh, B., Wilson, J.M. (2013) Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history. Proceedings. Biological sciences. 281:20132669
- Davey, C., Tallafuss, A., and Washbourne, P. (2010) Differential expression of neuroligin genes in the nervous system of zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(2):703-714
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