Gene

thbs1b

ID
ZDB-GENE-020708-1
Name
thrombospondin 1b
Symbol
thbs1b Nomenclature History
Previous Names
  • thbs1
  • Tsp-1 (1)
  • si:dkey-11e23.1
  • wu:fc48c03
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have calcium ion binding activity; extracellular matrix binding activity; and heparin binding activity. Predicted to be involved in negative regulation of angiogenesis. Predicted to localize to collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in cholangiocarcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Is expressed in several structures, including axial vasculature; head mesenchyme; nervous system; pectoral fin; and somite. Orthologous to human THBS1 (thrombospondin 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With thbs1b Human Ortholog
No data available
Associated With thbs1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000742 EGF-like domain
Domain IPR001007 VWFC domain
Domain IPR001791 Laminin G domain
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR008859 Thrombospondin, C-terminal
Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily IPR028974 TSP type-3 repeat
Homologous_superfamily IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
Repeat IPR000884 Thrombospondin type-1 (TSP1) repeat
Repeat IPR003367 Thrombospondin, type 3-like repeat
Repeat IPR017897 Thrombospondin, type 3 repeat
Domain Details Per Protein
Protein Length Concanavalin A-like lectin/glucanase domain superfamily EGF-like calcium-binding domain EGF-like domain Laminin G domain Thrombospondin, C-terminal Thrombospondin type-1 (TSP1) repeat Thrombospondin type-1 (TSP1) repeat superfamily Thrombospondin, type 3-like repeat Thrombospondin, type 3 repeat TSP type-3 repeat VWFC domain
UniProtKB:F1QEE7 1170
UniProtKB:F1QL35 1171
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations