Gene
tbx18
- ID
- ZDB-GENE-020529-2
- Name
- T-box transcription factor 18
- Symbol
- tbx18 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including morphogenesis of embryonic epithelium; regulation of transcription by RNA polymerase II; and somitogenesis. Predicted to act upstream of or within positive regulation of DNA-templated transcription. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including fin bud; medial longitudinal fasciculus; pectoral fin; pericardial region; and proepicardial cluster. Human ortholog(s) of this gene implicated in CAKUT2. Orthologous to human TBX18 (T-box transcription factor 18).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 39 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu307 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa24370 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24371 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa29963 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32453 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| tpl116Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| tpl117 | Allele with one delins | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tbx18 | Burg et al., 2016 | |
| TALEN1-tbx18 | Xiao et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018186 | Transcription factor, T-box, conserved site |
| Domain | IPR046360 | T-box transcription factor, DNA-binding domain |
| Family | IPR001699 | T-box transcription factor |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR036960 | T-box superfamily |
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Domain Details Per Protein
| Protein | Length | p53-like transcription factor, DNA-binding domain superfamily | T-box superfamily | T-box transcription factor | T-box transcription factor, DNA-binding domain | Transcription factor, T-box, conserved site |
|---|---|---|---|---|---|---|
|
UniProtKB:Q8JFF9
|
554 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(tbx18:DsRed2) |
|
| 1 | (4) | |
| TgBAC(tbx18:EGFP) |
|
| 1 | (3) | |
| TgBAC(tbx18:MYR-Citrine) |
|
| 1 | Weinberger et al., 2020 | |
| TgBAC(tbx18:MYR-EGFP) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-197L9 | ZFIN Curated Data | |
| Encodes | EST | eu307 | Thisse et al., 2005 | |
| Encodes | EST | fc24a06 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194980 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195002 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_153665 (1) | 4303 nt | ||
| Genomic | GenBank:BX649257 (2) | 182686 nt | ||
| Polypeptide | UniProtKB:Q8JFF9 (1) | 554 aa |
- Ahuja, S., Adjekukor, C., Li, Q., Kocha, K.M., Rosin, N., Labit, E., Sinha, S., Narang, A., Long, Q., Biernaskie, J., Huang, P., Childs, S.J. (2024) The development of brain pericytes requires expression of the transcription factor nkx3.1 in intermediate precursors. PLoS Biology. 22:e3002590e3002590
- Carey, C.M., Hollins, H.L., Schmid, A.V., Gagnon, J.A. (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biology Open. 13(4):
- Xia, Y., Duca, S., Perder, B., Dündar, F., Zumbo, P., Qiu, M., Yao, J., Cao, Y., Harrison, M.R.M., Zangi, L., Betel, D., Cao, J. (2022) Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration. Nature communications. 13:77047704
- Abu Nahia, K., Migdał, M., Quinn, T.A., Poon, K.L., Łapiński, M., Sulej, A., Liu, J., Mondal, S.S., Pawlak, M., Bugajski, Ł., Piwocka, K., Brand, T., Kohl, P., Korzh, V., Winata, C. (2021) Genomic and physiological analyses of the zebrafish atrioventricular canal reveal molecular building blocks of the secondary pacemaker region. Cellular and molecular life sciences : CMLS. 78(19-20):6669-6687
- de Bakker, D.E.M., Bouwman, M., Dronkers, E., Simões, F.C., Riley, P.R., Goumans, M.J., Smits, A.M., Bakkers, J. (2021) Prrx1b restricts fibrosis and promotes Nrg1-dependent cardiomyocyte proliferation during zebrafish heart regeneration. Development (Cambridge, England). 148(19):
- Katraki-Pavlou, S., Kastana, P., Bousis, D., Ntenekou, D., Varela, A., Davos, C.H., Nikou, S., Papadaki, E., Tsigkas, G., Athanasiadis, E., Herradon, G., Mikelis, C.M., Beis, D., Papadimitriou, E. (2021) Protein tyrosine phosphatase receptor zeta 1 deletion triggers defective heart morphogenesis in mice and zebrafish. American journal of physiology. Heart and circulatory physiology. 322(1):H8-H24
- Missinato, M.A., Zuppo, D.A., Watkins, S.C., Bruchez, M.P., Tsang, M. (2021) Zebrafish heart regenerates after chemoptogenetic cardiomyocyte depletion. Developmental Dynamics : an official publication of the American Association of Anatomists. 250(7):986-1000
- Sun, Y., Yang, F., Liu, Y., Yu, M., Wu, F., Wang, G. (2021) Di-2-ethylhexyl phthalate induces heart looping disorders during zebrafish development. Toxicology and industrial health. 37(7):391-397
- Weinberger, M., Simões, F.C., Patient, R., Sauka-Spengler, T., Riley, P.R. (2020) Functional Heterogeneity within the Developing Zebrafish Epicardium. Developmental Cell. 52(5):574-590.e6
- Ban, H., Yokota, D., Otosaka, S., Kikuchi, M., Kinoshita, H., Fujino, Y., Yabe, T., Ovara, H., Izuka, A., Akama, K., Yamasu, K., Takada, S., Kawamura, A. (2019) Transcriptional autoregulation of zebrafish tbx6 is required for somite segmentation. Development (Cambridge, England). 146(18):
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