Gene
flot2a
- ID
- ZDB-GENE-020430-3
- Name
- flotillin 2a
- Symbol
- flot2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable protease binding activity. Acts upstream of or within regulation of cell-cell adhesion mediated by cadherin and regulation of epiboly involved in gastrulation with mouth forming second. Predicted to be located in endocytic vesicle and endosome. Predicted to be part of flotillin complex. Predicted to be active in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including fin; nervous system; pectoral fin bud; segmental plate; and trigeminal placode. Orthologous to human FLOT2 (flotillin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55821 (1 image)
- IMAGE:7143869 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Morris et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la025092Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la025094Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-flot2a | (2) | |
| CRISPR2-flot2a | Routledge et al., 2022 | |
| CRISPR3-flot2a | Routledge et al., 2022 | |
| MO1-flot2a | N/A | Munderloh et al., 2009 |
| MO2-flot2a | N/A | Munderloh et al., 2009 |
| MO3-flot2a | N/A | Morris et al., 2017 |
| MO4-flot2a | N/A | Morris et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Band 7 domain | Band 7/SPFH domain superfamily | Flotillin, C-terminal domain | Flotillin family |
|---|---|---|---|---|---|---|
| UniProtKB:Q98TZ8 | InterPro | 428 | ||||
| UniProtKB:A0A8M3B9S2 | InterPro | 363 | ||||
| UniProtKB:A0A8M2BCI4 | InterPro | 428 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
flot2a-202
(1)
|
Ensembl | 544 nt | ||
| mRNA |
flot2a-201
(1)
|
Ensembl | 2,014 nt | ||
| ncRNA |
flot2a-003
(1)
|
Ensembl | 647 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-210G19 | ZFIN Curated Data | |
| Encodes | EST | fb48a04 | ||
| Encodes | EST | IMAGE:7143869 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:55821 | ||
| Encodes | cDNA | MGC:193094 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213075 (1) | 3054 nt | ||
| Genomic | GenBank:BX323596 (2) | 251428 nt | ||
| Polypeptide | UniProtKB:A0A8M2BCI4 (1) | 428 aa |
- Routledge, D., Rogers, S., Ono, Y., Brunt, L., Meniel, V., Tornillo, G., Ashktorab, H., Phesse, T., Scholpp, S. (2022) The scaffolding protein Flot2 promotes cytoneme-based transport of Wnt3 in gastric cancer. eLIFE. 11:
- Casey, M.A., Hill, J.T., Hoshijima, K., Bryan, C.D., Gribble, S.L., Brown, J.T., Chien, C.B., Yost, H.J., Kwan, K.M. (2021) Shutdown corner, a large deletion mutant isolated from a haploid mutagenesis screen in zebrafish. G3 (Bethesda). 12(3):
- Saddala, M.S., Lennikov, A., Bouras, A., Huang, H. (2020) RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio. BMC Genomics. 21:132
- Zheng, M., Lu, J., Zhao, D. (2018) Toxicity and Transcriptome Sequencing (RNA-seq) Analyses of Adult Zebrafish in Response to Exposure Carboxymethyl Cellulose Stabilized Iron Sulfide Nanoparticles. Scientific Reports. 8:8083
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Morris, E.A., Bodin, S., Delaval, B., Comunale, F., Georget, V., Costa, M.L., Lutfalla, G., Gauthier-Rouvière, C. (2017) Flotillins control zebrafish epiboly through their role in cadherin-mediated cell-cell adhesion. Biology of the cell. 109(5):210-221
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Desvignes, T., Detrich, H.W., Postlethwait, J.H. (2016) Genomic conservation of erythropoietic microRNAs (erythromiRs) in white-blooded Antarctic icefish. Marine genomics. 30:27-34
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
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