Research
General Information
ZIRC
ZFIN: Gene: ache
ZFIN ID: ZDB-GENE-010906-1

Gene Name:acetylcholinesterase
Gene Symbol: ache
Previous Names: zim(1) , ziehharmonika(1) , zgc:92550
Nomenclature History


GENE EXPRESSION:(current status)
All expression data: 12 figure(s) from 7 publications
Directly submitted expression data: 6 figure(s) (6 images) from Thisse et al., 2005 [eu3]
Wild Type Stages, Structures: Blastula:Sphere (4.00h-4.33h) to Adult (90d-730d, breeding adult)
  brain, hindbrain ... (all 9)
Curated microarray expression: GEO  (1)

MUTANTS AND TARGETED KNOCKDOWNS:
Mutant line(s):   9 genotypes
Allele(s):   sb55, tf222a, tm205, tm206
Phenotype: (current status)
  Data: 14 figures from 5 publications
  Observed in: acetylcholinesterase activity, apoptosis, associative learning, axon, axon guidance ... (all 26)
Knockdown reagent: MO1-ache (1)

GENE PRODUCTS:

Gene Ontology
Ontology GO Term
Biological Process acetylcholine catabolic process (more)
Cellular Component cell junction (more)
Molecular Function acetylcholinesterase activity (more)
All GO Terms (18)

Protein Families, Domains and Sites:
  • InterPro:IPR000997 (1)
  • InterPro:IPR002018 (1)
  • InterPro:IPR014788 (1)
  • InterPro:IPR019819 (1)
  • InterPro:IPR019826 (1)
  • PROSITE:PS00122 (1)
  • PROSITE:PS00941 (1)
  • Pfam:PF00135 (1)
  • Pfam:PF08674 (1)
  • EC:3.1.1.7 (1)
  • Loading Transcript Data...

    Gene Product Description


    SEGMENT (CLONE AND PROBE) RELATIONSHIPS:
    ache Contained in [BAC] CH211-153N19 (1)    (order this) , CH211-196F2 (1)    (order this)
    ache Encodes [EST] eu3 (1)
    [cDNA] MGC:92550 (1)    (order this) , MGC:195318 (1)    (order this) , MGC:195325 (1)    (order this)

    SEQUENCE INFORMATION:
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131846 (1) 2556 bp
    Genomic GenBank:BX470232 (1) 194721 bp
    Polypeptide UniProtKB:B3DKL4 (1) 634 aa
    Sequence Clusters UniGene:133438 (1)
    All Sequence Information (16)

    OTHER  ache  GENE / MARKER PAGES:

  • Entrez Gene:114549 (1)
  • VEGA:OTTDARG00000020126 (1)
  • Ensembl(Zv8):ENSDARG00000031796 (1)

  • MAPPING INFORMATION:
      LG:  7    Details   View Map: Merged  Individual Panels

    ORTHOLOGY:
      Evidence
    Species Symbol Chromosome (Position) Accession # CL
    Zebrafish ache  7
    Human ACHE  7 (q22)
  • OMIM:100740
  • Entrez Gene:43
  • Mouse Ache  5 (77.00 cM)
  • MGI:87876
  • Entrez Gene:11423
  • Orthology Details

    CITATIONS   (34)