Gene
sim2
- ID
- ZDB-GENE-010803-1
- Name
- SIM bHLH transcription factor 2
- Symbol
- sim2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have DNA binding activity; DNA-binding transcription factor activity; and protein dimerization activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to localize to cytoplasm; nucleus; and transcription factor complex. Is expressed in diencephalon; midbrain; pharyngeal arch; and presumptive diencephalon. Orthologous to human SIM2 (SIM bHLH transcription factor 2).
- Genome Resources
-
- Alliance (1)
- Gene:114450 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
-
- GEO (1) Expression Atlas (1) Single Cell Expression Atlas (1) Daniocell (1)
- Thisse Expression Data
-
- MGC:76842 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Al-Kurbi et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000014 | PAS domain |
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR013655 | PAS fold-3 |
| Domain | IPR013767 | PAS fold |
| Family | IPR001067 | Nuclear translocator |
| Homologous_superfamily | IPR035965 | PAS domain superfamily |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
| Repeat | IPR001610 | PAC motif |
Domain Details Per Protein
| Protein | Length | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Nuclear translocator | PAC motif | PAS domain | PAS domain superfamily | PAS fold | PAS fold-3 |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q8UVV3
|
585 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance