ZFIN is now using GRCz12tu for Genomic Data
Gene
sptb
- ID
- ZDB-GENE-000906-1
- Name
- spectrin, beta, erythrocytic
- Symbol
- sptb Nomenclature History
- Previous Names
-
- b-spectrin (1)
- fa09g12
- riesling
- ris
- wu:fa09g12
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable actin filament binding activity. Acts upstream of or within embryonic hemopoiesis and erythrocyte development. Predicted to be located in cytoplasm and spectrin-associated cytoskeleton. Predicted to be part of spectrin. Predicted to be active in cell junction; cortical actin cytoskeleton; and plasma membrane. Is expressed in intermediate cell mass of mesoderm. Used to study hereditary spherocytosis. Human ortholog(s) of this gene implicated in hereditary elliptocytosis; hereditary spherocytosis; and hereditary spherocytosis type 2. Orthologous to human SPTB (spectrin beta, erythrocytic).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary spherocytosis type 2 | Alliance | Spherocytosis, type 2 | 616649 |
| Anemia, neonatal hemolytic, fatal or near-fatal | 617948 | ||
| Elliptocytosis-3 | 617948 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| hereditary spherocytosis | sptbtb237/tb237 | standard conditions | Liao et al., 2000 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001589 | Actinin-type actin-binding domain, conserved site |
| Domain | IPR001605 | Pleckstrin homology domain, spectrin-type |
| Domain | IPR001715 | Calponin homology domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR041681 | Pleckstrin homology domain 9 |
| Family | IPR016343 | Spectrin, beta subunit |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR036872 | CH domain superfamily |
| Repeat | IPR002017 | Spectrin repeat |
| Repeat | IPR018159 | Spectrin/alpha-actinin |
Domain Details Per Protein
| Protein | Additional Resources | Length | Actinin-type actin-binding domain, conserved site | Calponin homology domain | CH domain superfamily | PH-like domain superfamily | Pleckstrin homology domain | Pleckstrin homology domain 9 | Pleckstrin homology domain, spectrin-type | Spectrin/alpha-actinin | Spectrin, beta subunit | Spectrin repeat |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B5B6 | InterPro | 2481 | ||||||||||
| UniProtKB:F1QQE5 | InterPro | 2357 | ||||||||||
| UniProtKB:Q9DGM6 | InterPro | 2357 | ||||||||||
| UniProtKB:A0AC58HNL4 | InterPro | 2357 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers