Gene
ngfb
- ID
- ZDB-GENE-000629-2
- Name
- nerve growth factor b (beta polypeptide)
- Symbol
- ngfb Nomenclature History
- Previous Names
-
- NGF
- ngf
- ngfb (1)
- ns:zft386
- xx:zft386
- zgc:109730
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have growth factor activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of neuron apoptotic process; and nervous system development. Predicted to localize to several cellular components, including axon; dendrite; and synaptic vesicle. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal failure; hereditary sensory and autonomic neuropathy type 5; interstitial cystitis; and neurogenic bladder. Is expressed in several structures, including alar plate midbrain region; head mesenchyme; nervous system; periderm; and segmental plate. Orthologous to human NGF (nerve growth factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109730 (16 images)
- eu513 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary sensory and autonomic neuropathy type 5 | Alliance | Neuropathy, hereditary sensory and autonomic, type V | 608654 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cystine-knot cytokine | Nerve growth factor conserved site | Nerve growth factor-like | Nerve growth factor-related |
|---|---|---|---|---|---|
|
UniProtKB:Q6YBR5
|
194 | ||||
|
UniProtKB:A0A8M1PAS0
|
224 | ||||
|
UniProtKB:B2GR51
|
194 |
Interactions and Pathways
No data available
Plasmids
No data available