Research
General Information
ZIRC
ZFIN ID: ZDB-LAB-040720-1
Sudipto Roy Lab
Institute of Molecular and Cell Biology
Proteos, 61 Biopolis Drive,
Singapore 138673
REPUBLIC OF SINGAPORE
Contact Info:
Contact Person: Roy, Sudipto
Phone: 65 6586 9744
Fax: 65 6779 1117
Email: sudiptor@imcb.a-star.edu.sg
URL: http://www.imcb.a-star.edu.sg/research/research_group/development_biology/6000000107_article.html
Line Designation: sq 		Lab Members:
Roy, Sudipto , PI/Director
Srinivas, B. P. , Post-Doc
Liew, Hoe Peng , Graduate Student
Lee, Ban Chuan , Research Staff
Leong, Wan Ying , Research Staff
Ng, Teclise , Research Staff
Tay, Shang Yew , Research Staff
Statement of Research Interests:

Zebrafish Publications of Lab members :
Rochlin, K., Yu, S., Roy, S., and Baylies, M.K. (2010) Myoblast fusion: When it takes more to make one. Dev. Biol.. 341(1):66-83
Tay, S.Y., Yu, X., Wong, K.N., Panse, P., Ng, C.P., and Roy, S. (2010) The iguana/DZIP1 protein is a novel component of the ciliogenic pathway essential for axonemal biogenesis. Dev. Dyn.. 239(2):527-534
Bessarab, D.A., Chong, S.W., Srinivas, B.P., and Korzh, V. (2008) Six1a is required for the onset of fast muscle differentiation in zebrafish. Dev. Biol.. 323(2):216-228
Liew, H.P., Choksi, S.P., Wong, K.N., and Roy, S. (2008) Specification of vertebrate slow-twitch muscle fiber fate by the transcriptional regulator Blimp1. Dev. Biol.. 324(2):226-235
Yu, X., Ng, C.P., Habacher, H., and Roy, S. (2008) Foxj1 transcription factors are master regulators of the motile ciliogenic program. Nat. Genet.. 40(12):1445-1453
Roy, S. (2007) Genetic analysis of the vertebrate hedgehog-signaling pathway using muscle cell fate specification in the zebrafish embryo. Methods Mol. Biol.. 397(1):55-66
Srinivas, B.P., Woo, J., Leong, W.Y., and Roy, S. (2007) A conserved molecular pathway mediates myoblast fusion in insects and vertebrates. Nat. Genet.. 39(6):781-786
Lee, B.C., and Roy, S. (2006) Blimp-1 is an essential component of the genetic program controlling development of the pectoral limb bud. Dev. Biol.. 300(2):623-634
Xu, J., Srinivas, B.P., Tay, S.Y., Mak, A., Yu, X., Lee, S.G., Yang, H., Govindarajan, K.R., Leong, B., Bourque, G., Mathavan, S., and Roy, S. (2006) Genome-wide Expression Profiling in the Zebrafish Embryo Identifies Target Genes Regulated by Hedgehog Signaling During Vertebrate Development. Genetics. 174(2):735-752
Tay, S.Y., Ingham, P.W., and Roy, S. (2005) A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo. Development. 132(4):625-634
Baxendale, S., Davison, C., Muxworthy, C., Wolff, C., Ingham, P.W., and Roy, S. (2004) The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling. Nat. Genet.. 36(1):88-93
Nakano, Y., Kim, H.R., Kawakami, A., Roy, S., Schier, A.F., and Ingham, P.W. (2004) Inactivation of dispatched 1 by the chameleon mutation disrupts Hedgehog signalling in the zebrafish embryo. Dev. Biol.. 269(2):381-392
Roy, S., and Ng, T. (2004) Blimp-1 specifies neural crest and sensory neuron progenitors in the zebrafish embryo. Curr. Biol.. 14(19):1772-1777
Wolff, C., Roy, S., Lewis, K.E., Schauerte, H., Joerg-Rauch, G., Kirn, A., Weiler, C., Geisler, R., Haffter, P., Ingham, P.W. (2004) iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo. Genes Dev.. 18(13):1565-1576
Wolff, C., Roy, S., and Ingham, P.W. (2003) Multiple muscle cell identities induced by distinct levels and timing of hedgehog activity in the zebrafish embryo. Curr. Biol.. 13(14):1169-1181
Roy, S., Qiao, T., Wolff, C., and Ingham, P.W. (2001) Hedgehog signaling pathway is essential for pancreas specification in the zebrafish embryo. Curr. Biol.. 11(17):1358-1363
Roy, S., Wolff, C., and Ingham, P.W. (2001) The u-boot mutation identifies a Hedgehog-regulated myogenic switch for fiber-type diversification in the zebrafish embryo. Genes Dev.. 15(12):1563-1576
Lewis, K.E., Currie, P.D., Roy, S., Schauerte, H., Haffter, P., and Ingham, P.W. (1999) Control of muscle cell-type specification in the zebrafish embryo by hedgehog signalling. Dev. Biol.. 216(2):469-480
Roy, S. (1994) Development of the zebrafish nervous system: Mechanisms of cellfate specification and axonal pathfinding in the central nervous system and periphery. Curr. Sci. Bangalore. 66(9):629-633