PUBLICATION
Development of the hypochord and dorsal aorta in the zebrafish embryo (Danio rerio)
- Authors
- Eriksson, J. and Löfberg, J.
- ID
- ZDB-PUB-000621-3
- Date
- 2000
- Source
- Journal of morphology 244(3): 167-176 (Journal)
- Registered Authors
- Löfberg, Jan
- Keywords
- zebrafish embryo; hypochord; dorsal aorta; vasculogenesis; development
- MeSH Terms
-
- Animals
- Aorta/embryology
- Aorta/growth & development
- Aorta/ultrastructure
- Embryo, Nonmammalian
- Microscopy, Electron
- Morphogenesis
- Notochord/embryology
- Notochord/growth & development
- Notochord/ultrastructure
- Zebrafish/anatomy & histology
- Zebrafish/embryology*
- PubMed
- 10815000 Full text @ J. Morphol.
Citation
Eriksson, J. and Löfberg, J. (2000) Development of the hypochord and dorsal aorta in the zebrafish embryo (Danio rerio). Journal of morphology. 244(3):167-176.
Abstract
The hypochord of the zebrafish embryo (Danio rerio) emerges at the 9-somite stage as a single row of cells in the dorsomedial endoderm immediately ventral to the notochord. It is recognizable from the 2(nd) or 3(rd) somite and extends along the trunk to the same extent as the somites. A basal lamina surrounds the hypochord and its cells are slightly larger than the nearby endoderm cells. TEM studies have shown that the hypochord cells contain, in addition to mitochondria, well-developed rough endoplasmic reticula and Golgi networks, indicating synthetic activity. Once formed, the hypochord will stay in close association with the notochord, and this axial complex gradually moves dorsally, separating the hypochord from the endoderm as a one-cell-wide, rod-like structure that is bean-shaped in transverse section. This is the situation in the 15-somite embryo, at the level of the 4-5(th) somites. In the gap between the hypochord and the endoderm, angioblast cells aggregate and start to form the dorsal aorta, which becomes intimately associated with the hypochord. In the 17-somite embryo the aortic rudiment is established just ventral to the hypochord as a tube with a lumen. As development proceeds, the size of the hypochord decreases. In the pec fin embryo the hypochord is still recognizable in the posterior trunk, but has apparently vanished in anterior regions. The temporal correlation between the appearance of the hypochord and the formation of the dorsal aorta, coupled with the intimate relationship between these structures, suggest that the hypochord may play a role in the positioning of the dorsal aorta.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping