ZFIN Lab: P. Paul Liu Lab

ZFIN ID: ZDB-LAB-001018-1

P. Paul Liu Lab

PI/Director:	Liu, Pu Paul
Contact Person:	Diemer, Jamie
Email:	jamie.diemer@nih.gov
URL:	http://www.genome.gov/Staff/Liu/
Address:	National Human Genome Research Group The National Institutes of Health 49 Convent Drive Building 49, Room 3A18 Bethesda, MD 20892 USA
Country:	United States
Phone:	(301) 402-2341
Fax:	(301) 402-4929
Line Designation:	hg

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 7 genomic features

STATEMENT OF RESEARCH INTERESTS

Our reseach focuses on zebrafish models of hematopoetic diseases and malignancies.

LAB MEMBERS

Bresciani, Erica Post-Doc

Diemer, Jamie Administrative Staff

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

García-López, J.P., Grimaldi, A., Chen, Z., Meneses, C., Bravo-Tello, K., Bresciani, E., Banderas, A., Burgess, S.M., Hernández, P.P., Feijoo, C.G. (2023) Author Correction: Ontogenetically distinct neutrophils differ in function and transcriptional profile in zebrafish. Nature communications. 14:52925292

García-López, J.P., Grimaldi, A., Chen, Z., Meneses, C., Bravo-Tello, K., Bresciani, E., Banderas, A., Burgess, S.M., Hernández, P.P., Feijoo, C.G. (2023) Ontogenetically distinct neutrophils differ in function and transcriptional profile in zebrafish. Nature communications. 14:49424942

Sinclair, J.W., Hoying, D.R., Bresciani, E., Nogare, D.D., Needle, C.D., Berger, A., Wu, W., Bishop, K., Elkahloun, A.G., Chitnis, A., Liu, P., Burgess, S.M. (2021) The Warburg effect is necessary to promote glycosylation in the blastema during zebrafish tail regeneration. NPJ Regenerative medicine. 6:55

Bresciani, E., Carrington, B., Yu, K., Kim, E.M.K., Zhen, T., Guzman, V.S., Broadbridge, E., Bishop, K., Kirby, M., Harper, U., Wincovitch, S., Dell'Orso, S., Sartorelli, V., Sood, R., Liu, P.P. (2021) Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development. Blood advances. 5(23):4949-4962

Mazzola, M., Pezzotta, A., Fazio, G., Rigamonti, A., Bresciani, E., Gaudenzi, G., Pelleri, M.C., Saitta, C., Ferrari, L., Parma, M., Fumagalli, M., Biondi, A., Cazzaniga, G., Marozzi, A., Pistocchi, A. (2020) Dysregulation of NIPBL leads to impaired RUNX1 expression and haematopoietic defects. Journal of Cellular and Molecular Medicine. 24(11):6272-6282

Mazzola, M., Deflorian, G., Pezzotta, A., Ferrari, L., Fazio, G., Bresciani, E., Saitta, C., Ferrari, L., Fumagalli, M., Parma, M., Marasca, F., Bodega, B., Riva, P., Cotelli, F., Biondi, A., Marozzi, A., Cazzaniga, G., Pistocchi, A. (2019) NIPBL: a new player in myeloid cells differentiation. Haematologica. 104(7):1332-1341

Bresciani, E., Broadbridge, E., Liu, P.P. (2018) An efficient dissociation protocol for generation of single cell suspension from zebrafish embryos and larvae. MethodsX. 5:1287-1290

Gore, A.V., Athans, B., Iben, J.R., Johnson, K., Russanova, V., Castranova, D., Pham, V.N., Butler, M.G., Williams-Simons, L., Nichols, J.T., Bresciani, E., Feldman, B., Kimmel, C.B., Liu, P.P., Weinstein, B.M. (2016) Epigenetic regulation of hematopoiesis by DNA methylation. eLIFE. 5:e11813

Colombo, E.A., Carra, S., Fontana, L., Bresciani, E., Cotelli, F., Larizza, L. (2015) A zebrafish model of Poikiloderma with Neutropenia recapitulates the human syndrome hallmarks and traces back neutropenia to the myeloid progenitor. Scientific Reports. 5:15814

Connelly, J.P., Kwon, E.M., Gao, Y., Trivedi, N.S., Elkahloun, A.G., Horwitz, M.S., Cheng, L., Liu, P.P. (2014) Targeted correction of RUNX1 mutation in FPD patient-specific induced pluripotent stem cells rescues megakaryopoietic defects. Blood. 124(12):1926-30

Hao, H., Veleri, S., Sun, B., Kim, D.S., Keeley, P.W., Kim, J.W., Yang, H.J., Yadav, S.P., Manjunath, S.H., Sood, R., Liu, P., Reese, B.E., Swaroop, A. (2014) Regulation of a novel isoform of Receptor Expression Enhancing Protein REEP6 in rod photoreceptors by bZIP transcription factor NRL. Human molecular genetics. 23(16):4260-71

Bresciani, E., Carrington, B., Wincovitch, S., Jones, M., Gore, A.V., Weinstein, B.M., Sood, R., Liu, P.P. (2014) CBFβ and RUNX1 are required at 2 different steps during the development of hematopoietic stem cells in zebrafish. Blood. 124(1):70-8

Cermenati, S., Moleri, S., Neyt, C., Bresciani, E., Carra, S., Grassini, D.R., Omini, A., Goi, M., Cotelli, F., François, M., Hogan, B.M., and Beltrame, M. (2013) Sox18 Genetically Interacts With VegfC to Regulate Lymphangiogenesis in Zebrafish. Arterioscler. Thromb. Vasc. Biol.. 33(6):1238-47

Cunningham, L., Finckbeiner, S., Hyde, R.K., Southall, N., Marugan, J., Yedavalli, V.R., Dehdashti, S.J., Reinhold, W.C., Alemu, L., Zhao, L., Yeh, J.R., Sood, R., Pommier, Y., Austin, C.P., Jeang, K.T., Zheng, W., and Liu, P. (2012) Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFbeta interaction. Proceedings of the National Academy of Sciences of the United States of America. 109(36):14592-14597

Jin, H., Li, L., Xu, J., Zhen, F., Zhu, L., Liu, P.P., Zhang, M., Zhang, W., and Wen, Z. (2012) Runx1 regulates embryonic myeloid fate choice in zebrafish through a negative feedback loop inhibiting Pu.1 expression. Blood. 119(22):5239-5249

Sood, R., and Liu, P. (2012) Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models. Advances in hematology. 2012:830703

Finckbeiner, S., Ko, P.J., Carrington, B., Sood, R., Gross, K., Dolnick, B., Sufrin, J., and Liu, P. (2011) Transient Knockdown and Overexpression Reveal a Developmental Role for the Zebrafish enosf1b Gene. Cell & Bioscience. 1:32

Sood, R., English, M.A., Belele, C.L., Jin, H., Bishop, K., Haskins, R., McKinney, M.C., Chahal, J., Weinstein, B.M., Wen, Z., and Liu, P.P. (2010) Development of multilineage adult hematopoiesis in the zebrafish with a runx1 truncation mutation. Blood. 115(14):2806-2809

Belele, C.L., English, M.A., Chahal, J., Burnetti, A., Finckbeiner, S.M., Gibney, G., Kirby, M., Sood, R., and Liu, P. (2009) Differential requirement for Gata1 DNA binding and transactivation between primitive and definitive stages of hematopoiesis in zebrafish. Blood. 114(25):5162-5172

Jin, H., Sood, R., Xu, J., Zhen, F., English, M.A., Liu, P.P., and Wen, Z. (2009) Definitive hematopoietic stem/progenitor cells manifest distinct differentiation output in the zebrafish VDA and PBI. Development (Cambridge, England). 136(4):647-654

Sood, R., English, M.A., Jones, M., Mullikin, J., Wang, D.M., Anderson, M., Wu, D., Chandrasekharappa, S.C., Yu, J., Zhang, J., and Liu, P.P. (2006) Methods for reverse genetic screening in zebrafish by resequencing and TILLING. Methods (San Diego, Calif.). 39(3):220-227

Nishikawa, K., Kobayashi, M., Masumi, A., Lyons, S.E., Weinstein, B.M.,Liu, P.P., and Yamamoto, M. (2003) Self-association of Gata1 enhances transcriptional activity in vivo in zebra fish embryos. Molecular and cellular biology. 23(22):8295-8305

Lyons, S.E., Lawson, N.D., Lei, L., Bennett, P.E., Weinstein, B.M., and Liu, P.P. (2002) A nonsense mutation in zebrafish gata1 causes the bloodless phenotype in vlad tepes. Proceedings of the National Academy of Sciences of the United States of America. 99(8):5454-5459

Lyons, S.E., Shue, B.C., Lei, L., Oates, A.C., Zon, L.I., and Liu, P.P. (2001) Molecular cloning, genetic mapping, and expression analysis of four zebrafish c/ebp genes. Gene. 281(1-2):43-51

Lyons, S.E., Shue, B.C., Oates, A.C., Zon, L.I., and Liu, P.P. (2001) A novel myeloid-restricted zebrafish CCAAT/enhancer-binding protein with a potent transcriptional activation domain. Blood. 97(9):2611-2617

Blake, T., Adya, N., Kim, C.H., Oates, A.C., Zon, L., Chitnis, A., Weinstein, B.M., and Liu, P.P. (2000) Zebrafish homolog of the leukemia gene CBFB: its expression during embryogenesis and its relationship to scl and gata-1 in hematopoiesis. Blood. 96(13):4178-4184

Lyons, S.E., Lawson, N.D., Bennett, P.J., Weinstein, B.M., and Liu, P.P. (2000) Nonsense mutation in gata1 identified in the "bloodless" zebrafish vlad tepes. Blood. 96(11):2400

Lyons, S.E., Shue, B.C., Oates, A.C., Zon, L.I., and Liu, P.P. (2000) A novel myeloid-restricted zebrafish C/EBP with a potent transcriptional activation domain. Blood. 96(11):2877