Gene
cryaba
- ID
- ZDB-GENE-991119-2
- Name
- crystallin, alpha B, a
- Symbol
- cryaba Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Enables unfolded protein binding activity. Acts upstream of or within several processes, including heart contraction; myofibril assembly; and skeletal muscle tissue development. Located in plasma membrane. Is expressed in several structures, including eye; heart; otic vesicle; presumptive neural retina; and solid lens vesicle. Human ortholog(s) of this gene implicated in cataract 16 multiple types; dilated cardiomyopathy 1II; fatal infantile hypertonic myofibrillar myopathy; and myofibrillar myopathy 2. Orthologous to human CRYAB (crystallin alpha B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cryaba | (2) | |
| CRISPR2-cryaba | (2) | |
| CRISPR3-cryaba | (2) | |
| CRISPR4-cryaba | (2) | |
| CRISPR5-cryaba | (2) | |
| MO1-cryaba | N/A | Bührdel et al., 2015 |
| MO2-cryaba | N/A | Zou et al., 2015 |
| MO3-cryaba | N/A | Mishra et al., 2018 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cataract 16 multiple types | Alliance | Cataract 16, multiple types | 613763 |
| dilated cardiomyopathy 1II | Alliance | Cardiomyopathy, dilated, 1II | 615184 |
| fatal infantile hypertonic myofibrillar myopathy | Alliance | Myopathy, myofibrillar, fatal infantile hypertonic, alpha-B crystallin-related | 613869 |
| myofibrillar myopathy 2 | Alliance | Myopathy, myofibrillar, 2 | 608810 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| cataract | cryabaasu2/asu2 | standard conditions | Posner et al., 2024 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Alpha crystallin/Hsp20 domain | Alpha-crystallin, N-terminal | Alpha crystallin/Small heat shock protein, animal type | HSP20-like chaperone |
|---|---|---|---|---|---|
|
UniProtKB:Q9PUR2
|
168 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cryaba-201
(1)
|
Ensembl | 1,335 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-262M14 | ZFIN Curated Data | |
| Encodes | EST | af159089 | ||
| Encodes | cDNA | MGC:193708 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193741 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131157 (1) | 900 nt | ||
| Genomic | GenBank:CR385077 (2) | 105764 nt | ||
| Polypeptide | UniProtKB:Q9PUR2 (1) | 168 aa |
- Posner, M., Garver, T., Kaye, T., Brdicka, S., Suttle, M., Patterson, B., Farnsworth, D.R. (2024) Loss of αBa-crystallin, but not αA-crystallin, increases age-related cataract in the zebrafish lens. Experimental Eye Research. 244:109918
- Posner, M., Murray, K.L., Andrew, B., Brdicka, S., Roberts, A., Franklin, K., Hussen, A., Kaye, T., Kepp, E., McDonald, M.S., Snodgrass, T., Zientek, K., David, L.L. (2022) Impact of α-crystallin protein loss on zebrafish lens development. Experimental Eye Research. 227:109358
- Farnsworth, D., Posner, M., Miller, A. (2021) Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development. Experimental Eye Research. 206:108535
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Cui, X., Feng, R., Wang, J., Du, C., Pi, X., Chen, D., Li, J., Li, H., Zhang, J., Zhang, J., Mu, H., Zhang, F., Liu, M., Hu, Y. (2019) Heat shock factor 4 regulates lysosome activity by modulating the αB-crystallin-ATP6V1A-mTOR complex in ocular lens. Biochimica et biophysica acta. General subjects. 1864(3):129496
- Posner, M., McDonald, M.S., Murray, K.L., Kiss, A.J. (2019) Why does the zebrafish cloche mutant develop lens cataract?. PLoS One. 14:e0211399
- Mercer, E.J., Lin, Y.F., Cohen-Gould, L., Evans, T. (2018) Hspb7 is a Cardioprotective Chaperone Facilitating Sarcomeric Proteostasis. Developmental Biology. 435(1):41-55
- Mishra, S., Wu, S.Y., Fuller, A.W., Wang, Z., Rose, K.L., Schey, K.L., Mchaourab, H.S. (2018) Loss of αB-crystallin function in zebrafish reveals critical roles in the development of the lens and stress resistance of the heart. The Journal of biological chemistry. 293(2):740-753
- Wu, S.Y., Zou, P., Mishra, S., Mchaourab, H.S. (2018) Transgenic zebrafish models reveal distinct molecular mechanisms for cataract-linked αA-crystallin mutants. PLoS One. 13:e0207540
- Posner, M., Murray, K.L., McDonald, M.S., Eighinger, H., Andrew, B., Drossman, A., Haley, Z., Nussbaum, J., David, L.L., Lampi, K.J. (2017) The zebrafish as a model system for analyzing mammalian and native α-crystallin promoter function.. PeerJ. 5:e4093
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