Gene
melk
- ID
- ZDB-GENE-990603-5
- Name
- maternal embryonic leucine zipper kinase
- Symbol
- melk Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have calcium ion binding activity; non-membrane spanning protein tyrosine kinase activity; and protein serine/threonine kinase activity. Involved in erythrocyte development and regulation of heart contraction. Predicted to localize to cell cortex and nucleus. Is expressed in several structures, including digestive system; immature eye; nervous system; pleuroperitoneal region; and proliferative region. Orthologous to human MELK (maternal embryonic leucine zipper kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56337 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Saito et al., 2005
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001772 | Kinase associated domain 1 (KA1) |
| Domain | IPR034673 | Maternal embryonic leucine zipper kinase, catalytic domain |
| Domain | IPR048637 | Maternal embryonic leucine zipper kinase, UBA domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR028375 | KA1 domain/Ssp2, C-terminal |
Domain Details Per Protein
| Protein | Length | KA1 domain/Ssp2, C-terminal | Kinase associated domain 1 (KA1) | Maternal embryonic leucine zipper kinase, catalytic domain | Maternal embryonic leucine zipper kinase, UBA domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QGZ6
|
676 |
Interactions and Pathways
No data available
Plasmids
No data available