Gene
tle3a
- ID
- ZDB-GENE-990415-86
- Name
- TLE family member 3, transcriptional corepressor a
- Symbol
- tle3a Nomenclature History
- Previous Names
-
- gro2
- sb:eu295
- sb:eu753
- zfgro2
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have repressing transcription factor binding activity and transcription corepressor activity. Involved in regulation of retinoic acid biosynthetic process and sclerotome development. Predicted to localize to nucleus and transcription factor complex. Is expressed in several structures, including axis; central nervous system; cranial ganglion; mesoderm; and neural rod. Orthologous to human TLE3 (TLE family member 3, transcriptional corepressor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu295 (17 images)
- eu753 (1 image)
- eu874 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Domain | IPR005617 | Groucho/TLE, N-terminal Q-rich domain |
| Family | IPR009146 | Groucho/transducin-like enhancer |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
Domain Details Per Protein
| Protein | Length | Groucho/TLE, N-terminal Q-rich domain | Groucho/transducin-like enhancer | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B607
|
761 | ||||||
|
UniProtKB:O13166
|
761 | ||||||
|
UniProtKB:B3DGV3
|
762 |
Interactions and Pathways
No data available
Plasmids
No data available