Gene
tie1
- ID
- ZDB-GENE-990415-55
- Name
- tyrosine kinase with immunoglobulin-like and EGF-like domains 1
- Symbol
- tie1 Nomenclature History
- Previous Names
-
- tie-1
- sb:eu718
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have transmembrane receptor protein tyrosine kinase activity. Involved in blood vessel development; endothelial cell-cell adhesion; and heart development. Predicted to localize to integral component of plasma membrane and receptor complex. Is expressed in several structures, including angioblastic mesenchymal cell; cardiovascular system; intermediate cell mass of mesoderm; pharyngeal arch; and ventral mesoderm. Orthologous to human TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 63 figures from 39 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu718 (16 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Lymphatic malformation 11 | 619401 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Family | IPR050122 | Receptor Tyrosine Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Length | EGF-like domain | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:O73792
|
184 | ||||||||||||||
|
UniProtKB:A0A2R8QM04
|
1027 | ||||||||||||||
|
UniProtKB:G1K2H0
|
1122 |
Interactions and Pathways
No data available
Plasmids
No data available